Accelerated phase chronic myelogenous leukemia
Accelerated phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which the disease is progressing.[1] In this phase, 10 to 19% of the cells in the blood and bone marrow are blast cells (immature blood cells). In the accelerated phase, these leukemia cells grow quickly.
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| Specialty | Hematology and oncology |
Symptoms
Common symptoms include fever, bone pain, and swollen spleen.[2]
Treatment
Patients treated with imatinib, dasatinib, and nilotinib have shown meaningful rates of hematologic and cytogenetic response.[3]
Prognosis
Prognosis is very poor once chronic myelogenous leukemia reaches the accelerated phase; it behaves similarly to acute myeloid leukemia.
References
- Moshe Talpaz (2002). "Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study". Blood. 99 (6): 1928–1937. doi:10.1182/blood.v99.6.1928. PMID 11877262. S2CID 29480569.
- "Chronic myelogenous leukemia (CML)".
- Shah, NP (Mar 2008). "Advanced CML: therapeutic options for patients in accelerated and blast phases". Journal of the National Comprehensive Cancer Network. 6 Suppl 2: S31–S36. PMID 18397679.
External links
- Accelerated phase chronic myelogenous leukemia entry in the public domain NCI Cancer Dictionary
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