Acenocoumarol
Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is generic, so is marketed under many brand names worldwide.[1]
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| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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| Routes of administration | Oral |
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| Metabolism | Hepatic |
| Elimination half-life | 8 to 11 hours |
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| ECHA InfoCard | 100.005.281  |
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| Formula | C19H15NO6 |
| Molar mass | 353.330 g·mol−1 |
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| Chirality | Racemic mixture |
| Melting point | 196 to 199 °C (385 to 390 °F) |
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References
External links
- Diseases Database (DDB): 29202
- Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol". Blood Coagul Fibrinolysis. 15 (8): 673–6. doi:10.1097/00001721-200412000-00007. PMID 15613922. S2CID 19214006.
- Lengyel M; SPORTIF-III Altanulmány Vizsgálói (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil. 145 (52): 2619–21. PMID 15724697.
- Ufer M (2005). "Comparative pharmacokinetics of vitamin Kd antagonists: warfarin, phenprocoumon and acenocoumarol". Clin Pharmacokinet. 44 (12): 1227–46. doi:10.2165/00003088-200544120-00003. PMID 16372822. S2CID 42970169.
- Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients". Br J Haematol. 133 (2): 183–7. doi:10.1111/j.1365-2141.2006.06007.x. hdl:10171/21989. PMID 16611310. S2CID 369821.
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