Phenindione
Phenindione is an anticoagulant which functions as a Vitamin K antagonist.
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| Routes of administration | Oral |
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| Protein binding | 88% |
| Elimination half-life | 5 to 10 hours |
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| ECHA InfoCard | 100.001.323  |
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| Formula | C15H10O2 |
| Molar mass | 222.243 g·mol−1 |
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Phenindione was introduced in the early 1950s. It acts similar to warfarin, but it has been associated with hypersensitivity reactions, so it is rarely used and warfarin is preferred.[1][2]
References
- Naisbitt DJ, Farrell J, Chamberlain PJ, Hopkins JE, Berry NG, Pirmohamed M, Park BK (June 2005). "Characterization of the T-cell response in a patient with phenindione hypersensitivity". The Journal of Pharmacology and Experimental Therapeutics. 313 (3): 1058–65. doi:10.1124/jpet.105.083758. PMID 15743920.
- Sweetman SC, ed. (2009). Martindale: The Complete Drug Reference (36th ed.). London: Pharmaceutical Press. "Phenindione", p. 1369.
External links
- Diseases Database (DDB): 30536
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