Aortic pressure
Central aortic blood pressure (CAP or CASP) is the blood pressure at the root of aorta. Studies have shown the importance of central aortic pressure and its implications in assessing the efficacy of antihypertensive treatment with respect to cardiovascular risk factors.[1] The traditional method of measuring blood pressure in the arms has been shown to underestimate the efficacy of medications such as amlodipine and overestimate the efficacy of those like atenolol. A clinical trial demonstrated that different medications for lowering blood pressure have different effects on the central aortic pressure and blood flow characteristics, despite producing similar branchial blood pressure readings. The study also indicated that the CAP is a better independent predictor of cardiovascular and kidney outcomes.[2]
References
- Avolio A (June 2008). "Central aortic blood pressure and cardiovascular risk: a paradigm shift?". Hypertension. 51 (6): 1470–1. doi:10.1161/HYPERTENSIONAHA.107.108910. PMID 18426994.
- Williams B, Lacy PS, Thom SM, et al. (March 2006). "Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study". Circulation. 113 (9): 1213–25. doi:10.1161/CIRCULATIONAHA.105.595496. PMID 16476843. Lay summary – University of Leicester (2006).
Further reading
- CAFE - The Conduit Artery Functional Endpoint Study
- Lehmann ED (February 2001). "Where is the evidence that radial artery tonometry can be used with a generalised transfer function to accurately and non-invasively predict central aortic blood pressure?". Journal of Human Hypertension. 15 (2): 145–6. doi:10.1038/sj.jhh.1001126. PMID 11317196.
- Williams B, Lacy PS, Thom SM, et al. (March 2006). "Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study". Circulation. 113 (9): 1213–25. doi:10.1161/CIRCULATIONAHA.105.595496. PMID 16476843.
- Roman MJ, Devereux RB, Kizer JR, et al. (July 2007). "Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study". Hypertension. 50 (1): 197–203. CiteSeerX 10.1.1.486.1588. doi:10.1161/HYPERTENSIONAHA.107.089078. PMID 17485598.
- McGhee BH, Bridges EJ (April 2002). "Monitoring arterial blood pressure: what you may not know". Critical Care Nurse. 22 (2): 60–4, 66–70, 73 passim. PMID 11961944.