Caspase-2

Caspase-2 (EC 3.4.22.55, ICH-1, NEDD-2, caspase-2L, caspase-2S, neural precursor cell expressed developmentally down-regulated protein 2, CASP-2, NEDD2 protein) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

Strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-
Caspase-2
Identifiers
EC number3.4.22.55
CAS number182372-14-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Caspase-2 is an initiator caspase, as are caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63).

References
  1. Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA (July 1994). "Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme". Genes & Development. 8 (14): 1613–26. doi:10.1101/gad.8.14.1613. PMID 7958843.
  2. Wang L, Miura M, Bergeron L, Zhu H, Yuan J (September 1994). "Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death". Cell. 78 (5): 739–50. doi:10.1016/S0092-8674(94)90422-7. PMID 8087842.
  3. Li H, Bergeron L, Cryns V, Pasternack MS, Zhu H, Shi L, Greenberg A, Yuan J (August 1997). "Activation of caspase-2 in apoptosis". The Journal of Biological Chemistry. 272 (34): 21010–7. doi:10.1074/jbc.272.34.21010. PMID 9261102.
  4. Mancini M, Machamer CE, Roy S, Nicholson DW, Thornberry NA, Casciola-Rosen LA, Rosen A (May 2000). "Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis". The Journal of Cell Biology. 149 (3): 603–12. doi:10.1083/jcb.149.3.603. PMC 2174848. PMID 10791974.
  5. Zhivotovsky B, Orrenius S (June 2005). "Caspase-2 function in response to DNA damage". Biochemical and Biophysical Research Communications. 331 (3): 859–67. doi:10.1016/j.bbrc.2005.03.191. PMID 15865942.
  6. Chang HY, Yang X (December 2000). "Proteases for cell suicide: functions and regulation of caspases". Microbiology and Molecular Biology Reviews. 64 (4): 821–46. doi:10.1128/mmbr.64.4.821-846.2000. PMC 99015. PMID 11104820.
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