Clobutinol
Clobutinol is a cough suppressant distributed by Boehringer Ingelheim, Novartis's Hexal (Sandoz), Stada and possibly other companies.
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | oral |
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| ECHA InfoCard | 100.035.373  |
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| Formula | C14H22ClNO |
| Molar mass | 255.79 g·mol−1 |
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| Chirality | Racemic mixture |
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Side effects and withdrawal
Studies in 2004 had indicated that clobutinol has the potential to prolong the QT interval.[1] Clobutinol was in 2007 determined to cause cardiac arrhythmia in some patients.[2]
Boehringer Ingelheim products containing clobutinol were voluntarily withdrawn from sale in Germany, and the rest of the world, on August 31, 2007.[3]
The approval for Germany and the EU was revoked in 2008.[4]
See also
References
- Bellocq C, Wilders R, Schott JJ, Louérat-Oriou B, Boisseau P, Le Marec H, et al. (November 2004). "A common antitussive drug, clobutinol, precipitates the long QT syndrome 2". Molecular Pharmacology. 66 (5): 1093–102. doi:10.1124/mol.104.001065. PMID 15280442.
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"Clobutinol-haltige Arzneimittel: BfArM ordnet Widerruf der Zulassung an". BfArM (German Federal Institute for Drugs and Medical Devices). 2007-08-31. Archived from the original on 2012-04-01.
Clobutinol: BfArM orders cancellation of approval
- "Boehringer Ingelheim voluntarily withdraws its clobutinol containing medications". Boehringer Ingelheim. 2007-08-31. Archived from the original on 2012-01-27.
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"Cancellation of approval" (PDF). BfArM (German Federal Institute for Drugs and Medical Devices). 2008-06-06. Archived from the original (pdf) on 2012-04-01.
Die Zulassungen für die o.g. Arzneimittel werden mit sofortiger Wirkung widerrufen.
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