Dominik Mysterio

Gutiérrez made his first professional wrestling appearance on the June 5, 2003 edition of SmackDown! at just 6 years old when he was in the crowd along with his mother Angie and his younger sister Aalyah watching his father Rey Mysterio win the WWE Cruiserweight Championship from Matt Hardy. After the match, Gutiérrez came over the barricade and into the ring to celebrate with his father, who promptly gave him a massive hug and hoisted him up on his shoulders. Gutiérrez made his second appearance on the December 11 edition of SmackDown! in the crowd again with Angie and Aalyah watching his father compete against WWE Champion Brock Lesnar in a non-title match in a losing effort.

In the summer of 2005, Gutiérrez made his third appearance in WWE at the age of 8 but this time in a more prominent role, as part of his father Rey's ongoing feud with Eddie Guerrero, in which the two rivals fought for custody of him. During the storyline, Guerrero stated that he was Dominik's (kayfabe) biological father.[8] Mysterio defeated Guerrero in a ladder match for custody of Dominik at SummerSlam, ending the feud.[9] He made two more appearances in 2006, first at WrestleMania 22 with Angie and Aalyah watching his father win the World Heavyweight Championship for the first time and second on the September 15 edition of SmackDown! where he watched backstage as his father battled with Mr. Kennedy. Mysterio would lose this match after Chavo Guerrero and Vickie Guerrero showed up on the stage with Gutiérrez to distract Mysterio as Kennedy rolled him up for the win. He once again appeared on the March 12, 2010 episode of SmackDown, this time during the feud between Rey Mysterio and the Straight Edge Society (CM Punk, Luke Gallows, and Serena).[10][11]

On the March 19, 2019, episode of SmackDown Live, Gutiérrez appeared on the show with his father, Rey Mysterio, who announced that he would be facing Samoa Joe at WrestleMania 35.[12] He once again appeared on Raw from April to June, during the feud between Mysterio and Joe.[13] During the following months, he was involved in his father's storylines and matches, including interfering in Rey's WWE Championship match against Brock Lesnar at Survivor Series.[14][15][16][17]

In May 2020, he again assisted his father, this time in dealing with Seth Rollins and his teammates Murphy and Austin Theory, after his father suffered a severe (kayfabe) eye injury.[18][19][20] At The Horror Show at Extreme Rules, Mysterio had his eye removed in an Eye for an Eye match, where the winner could only be declared upon removing an opponent's eyeball from its socket.[21] Dominik thereafter unsuccessfully came for revenge, having to be saved by his father's ally, Aleister Black.[22] On the August 3 episode of Raw, Dominik issued a challenge to Rollins, which he accepted for SummerSlam, in what was Dominik's in-ring debut.[23] The following week, after the SummerSlam match was made official, Rollins and Murphy attacked Dominik, landing over 30 kendo stick shots.[24] On August 23 at SummerSlam, Dominik made his in-ring debut, where he was defeated by Rollins in a Street Fight.[25] At Payback, Dominik teamed with his father to defeat Rollins and Murphy for his first victory in WWE. The next night on Raw, Dominik replaced his injured father in a match with Rollins, set up to determine entries into another match that was held later that night to decide the next challenger for the WWE Championship. Rollins avoided a frog splash, and went on to defeat Dominik, as a frustrated Rey looked on backstage. Next week he defeated Murphy with the help of his family in a Street Fight. The following week on Raw, he once again wrestled Rollins, this time in a steel cage match where he was defeated. A new storyline developed in September, where Dominik's sister began to show feelings for Murphy, the former disciple of Rollins. This caused unrest amongst the Mysterio family, and one such distraction caused Murphy to pin Dominik during a match.

As part of the 2020 Draft in October, Mysterio (along with his father and Seth Rollins) was drafted to the SmackDown brand.[26] The Mysterio family's feud with Rollins would end on the November 13 episode of SmackDown after Rey defeated Rollins in a No Holds Barred match after assistance from Murphy, who turned on Rollins. At the Survivor Series kickoff, Mysterio took part in a dual brand battle royal where but was the last person eliminated by The Miz. In January 2021, Dominik and Rey would begin a feud with King Corbin. On the January 22, episode of SmackDown Dominik was defeated by Corbin and would lose a rematch the following week. At the Royal Rumble, Dominik took part in his first rumble match where he eliminated Corbin before being eliminated by Bobby Lashley.