Flavivirin

Flavivirin (EC 3.4.21.91, Yellow fever virus (flavivirus) protease, NS2B-3 proteinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Selective hydrolysis of -Xaa-Xaa-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala
Flavivirin
Identifiers
EC number3.4.21.91
CAS number154215-26-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is present in classical flaviviruses (yellow fever, dengue fever).

References
  1. Chambers TJ, Hahn CS, Galler R, Rice CM (1990). "Flavivirus genome organization, expression, and replication". Annual Review of Microbiology. 44: 649–88. doi:10.1146/annurev.mi.44.100190.003245. PMID 2174669.
  2. Cahour A, Falgout B, Lai CJ (March 1992). "Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease". Journal of Virology. 66 (3): 1535–42. PMC 240879. PMID 1531368.
  3. Lin C, Amberg SM, Chambers TJ, Rice CM (April 1993). "Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site". Journal of Virology. 67 (4): 2327–35. PMC 240389. PMID 8445732.
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