KLK9

Kallikrein-related peptidase 9 also known as KLK9 is an enzyme which in humans is encoded by the KLK9 gene.[5]

KLK9
Identifiers
AliasesKLK9, KLK-L3, KLKL3, kallikrein related peptidase 9
External IDsOMIM: 605504 MGI: 1921082 HomoloGene: 40832 GeneCards: KLK9
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.41Start51,002,508 bp[1]
End51,009,634 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

284366

101533

Ensembl

ENSG00000213022

ENSMUSG00000047884

UniProt

Q9UKQ9

Q32M27

RefSeq (mRNA)

NM_012315

NM_028660

RefSeq (protein)

NP_036447

NP_082936

Location (UCSC)Chr 19: 51 – 51.01 MbChr 7: 43.79 – 43.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues.[6][7][8] KLK9 is primarily expressed in thymus, testis, spinal cord, cerebellum, trachea, mammary gland, prostate, brain, salivary gland, ovary, and skin.[5]

Clinical significance

KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines and is a potential prognostic marker for early-stage ovarian[9] and breast cancer patients.[10]

References
  1. GRCh38: Ensembl release 89: ENSG00000213022 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000047884 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yousef GM, Diamandis EP (April 2000). "The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9)". Genomics. 65 (2): 184–94. doi:10.1006/geno.2000.6159. PMID 10783266.
  6. "Entrez Gene: KLK9".
  7. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biological Chemistry. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
  8. Diamandis EP, Deperthes D, Lundwall Å (June 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
  9. Yousef GM, Kyriakopoulou LG, Scorilas A, Fracchioli S, Ghiringhello B, Zarghooni M, Chang A, Diamandis M, Giardina G, Hartwick WJ, Richiardi G, Massobrio M, Diamandis EP, Katsaros D (November 2001). "Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker". Cancer Research. 61 (21): 7811–8. PMID 11691797.
  10. Yousef GM, Scorilas A, Nakamura T, Ellatif MA, Ponzone R, Biglia N, Maggiorotto F, Roagna R, Sismondi P, Diamandis EP (March 2003). "The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer". Breast Cancer Research and Treatment. 78 (2): 149–58. doi:10.1023/A:1022931403825. PMID 12725415. S2CID 6515644.

Further reading
  • Yousef GM, Kyriakopoulou LG, Scorilas A, Fracchioli S, Ghiringhello B, Zarghooni M, Chang A, Diamandis M, Giardina G, Hartwick WJ, Richiardi G, Massobrio M, Diamandis EP, Katsaros D (November 2001). "Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker". Cancer Research. 61 (21): 7811–8. PMID 11691797.
  • Yousef GM, Luo LY, Diamandis EP (1999). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4". Anticancer Research. 19 (4B): 2843–52. PMID 10652563.
  • Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, Moss P, Paeper B, Wang K (October 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
  • The MEROPS online database for peptidases and their inhibitors: S01.307
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