Genome Valley

Genome Valley is an Indian high-technology business district spread across 25 km² in Hyderabad, India.[2][3] It is located across the suburbs, Turakapally, Shamirpet, Medchal, Uppal, Patancheru, Jeedimetla, Gachibowli and Keesara, the Valley has developed as a cluster for Biomedical research, training and manufacturing.[4][5][6]

Genome Valley
TypeScience Parks
IndustryBiotechnology
Bioinformatics
Biopharmaceutical
Vaccine
Clinical
Founded1999
FounderN. Chandrababu Naidu[1]
Headquarters
Shamirpet
,
Hyderabad
Websitegenomevalley.co
www.mnpark.in
www.ikpknowledgepark.com
www.innopolis-gv.com
www.genopolisgv.in

Genome Valley was commissioned in 1999 as S. P. Biotech Park in a public-private partnership with Bharat Biotech International, and its founder Krishna Ella, alongside private infrastructure companies such as Shapoorji Pallonji Group and ICICI Bank.[7] The high-technology district was founded to exert the attention of Research and Development organizations and synergize the existence of present life-science companies. The State-of-art Infrastructure was developed, and the area of 25 km Radius was acknowledged as Pollution Free Cluster in the life-science zone. With the help of the Government of Telangana, infrastructure providers like Shapoorji Pallonji Biotech Park and ICICI Knowledge Park were developed in the years 2000 and 2001.[8] The ICICI Knowledge park was later renamed as IKP Knowledge Park.[9][10] In the last 20 years, Genome Valley has become home to over 200 organizations from various sectors and industries, including around 50 global majors having life sciences R&D and clean manufacturing facilities.[11] Indian companies that have their services there are Alembic Pharma, Bharat Biotech, Biological E, Laxai Avanti, Aurobindo Pharma, Laurus Labs, etc.[11][12] After the first part of the district, the next part of Genome Valley 2.0 was started with a vision to further upgradation of this cluster.[13][11]

Government support

With the aim of strengthening the local infrastructure and transforming Hyderabad into a global center for Life Science and Pharmaceutical industry, the Government of Telangana decided to lay the foundation of the Hi-tech district Genome valley. Spread over an area of 1500 acres the hi-tech district will be developed in 4 phases using the PPP model of development. Telangana Government dynamically supports the growth of a complete cluster by strategizing new framework policies. It has taken various necessary steps in the ongoing process of development of a Hi-tech district.[14]

  • In 2018 BioAsia Business Conference GoTs announced its plans to make Genome Valley the largest cluster in and signed a MoU in the with Singapore based Engineering and Urban and Infrastructure Consulting firm Surbana Jurong for preparing a roadmap and integrated masterplan Genome Valley 2.0.[15]
  • Implementation of the IALA policy in Genome Valley in Feb 2018; Industrial Area Local Authority (IALA) for industrial parks was implemented and IALA status was given to Genome valley to ensure Telangana State Industrial Infrastructure Corporation (TSIIC) to use the proceeds collected as property taxes/advertisement tax, etc., in the betterment of the cluster and the common infrastructure.[14]
  • In July 2018 State Government announced plans to establish ultra-modern B-Hub in Genome Valley to level up manufacturing activities to support biopharma-based Research and Development. The technology proposed B-Hub, with an estimated cost of ₹60 crores, would be set up through Public Private Partnership (PPP). The step was taken to give thrust to local firms to compete with global firms. The Department of Biotechnology, Government of India has agreed to partner with the Government of Telangana in this project.[16][17]
  • B-Hub will be a first of its kind initiative in the country. It will be featuring a scale-up manufacturing facility, along with a turnkey incubator/lab space module within a built-up area of 40,000 square feet. It has launched a web portal for the life sciences sector, aimed at creating an interface between the government, Industries, Research Institutions and Start-ups.[16][17]
  • Telangana State Industrial Infrastructure Corporation (TSIIC) and Industrial Development Authority (IDA) have been successful in setting up manufacturing clusters and improving the supporting infrastructure along a major highway.[14]
  • In 2018 project worth ₹800 crore were announced in Genome valley which include Biosimilars manufacturing, advanced pharma and Biotech R&D, formulation manufacturing and integrated turnkey lab-spaces for hi-tech research.[18]
  • Various steps were taken by the state government to accelerate biologics and Biosimilars development as part of Genome Valley 2.0 vision.[18]

History

Telangana: The Hyderabad Biocluster

Andhra Pradesh Government has identified life science sector as one of the prime sectors to boost the industrial growth in the state. To establish a world-class infrastructure in R&D, Manufacturing healthcare, and education the government has identified Genome valley as the first biotech cluster for a geographical concentration of Medical Institutions, Biotech Companies, Research & Development laboratories, etc.[19][14] The city has institutions and laboratories like the Indian Institute of Chemical Technology and Centre for Cellular and Molecular Biology. Both the institution are part of CSIR laboratories. It also has other institutions like the Centre for DNA Fingerprinting and Diagnostics, LV Prasad Eye Research Institute, ICRISAT & Osmania University which form the academic backbone of the bio-cluster. Andhra Pradesh is the second state in the country that announced a biotech policy in 2001. The APIDC (Andhra Pradesh Industrial Development Corporation) has launched the country’s first venture capital fund for biotechnology with a corpus of US$30 million as a joint venture with Dynam Venture East, US to fund start-up biotech companies. Many international level partnerships have been initiated for the development of this high-tech district which includes a tie-up with the Research Triangle Park in North Carolina in the US and tie-up of the University of Hyderabad with the Pacific Region Grid Middleware Program based in San Diego, California. Also, MoUs have been signed up with the Malaysian government to strengthen relations between Genome Valley of Andhra Pradesh and Bio Valley of Malaysia putting the focus on trade, investment, innovation for pharma, and biotech companies, and commercialization. Shapoorji Pallonji Biotech Park covers 75% of the first phase of the hi-tech district sprawling over 140 acres of land. This includes open plots on a freehold basis, the park includes a business enterprise zone and a technology incubation sector too. The ICICI Knowledge park covers 200 acres in the Turkapally area near Hyderabad. The first phase has 10 laboratory modules of 3,000 sft each, the second phase also has an occupancy of 60%. An integrated IPR facilitating cell has been set up at ICICIKP under the auspices of AP Technology Development Center, a joint venture between CII and the Government of AP and Technology Information Forecasting and Assessment Council. The park is facilitated with uninterrupted power and water supply. The government has invested ₹30 crores on water supply projects in the parks. An animal farm is proposed to be set up by ICMR for the test purpose for biotech companies. ₹20 crores has been set aside by DBT for setting up the country’s first incubator. Incubation fund has also been allocated to promoting start-up companies to scale up their production and to commercialize their products, for which IICT will provide technical assistance. The government is promoting an Agri biotech farm with ICRISAT which includes Applied Genomics Lab, Genetic Transformation Lab, Bioinformatics & Computational Genomics facility, Intellectual Property Management Office & Technology Innovation Center (TIC). The country’s first biotech farm is proposed at Parwada Vishakhapatnam. A marine biotech complex is proposed in the park in association with Andhra University which would focus on marine resources and work towards developing vaccines to prevent diseases in shrimps and other marine organisms, apart from research on marine foods, nutraceuticals and fisheries.[14][19]

Alexandria Knowledge Park SEZ

The Special Economic Zone was jointly promoted by the Shapoorji Pallonji Group and the Government of Andhra Pradesh as a Public-Private Partnership initiative.[20] In May 2009 APIIC announced to allot ₹30 acres of land to US-based Life Science Infrastructure firm Alexandria Real Estate Equities, Inc. (NYSE:ARE). The firm agreed to invest ₹200 million in the knowledge park. In June 2010 the firm through its affiliate gained a controlling stake in the operations and maintenance of Shapoorji Pallonji Biotech Park Private Limited (SPBP) and rebranded it as 'Alexandria Knowledge Park'.[21] The park is now spread over 300 acres of land and integrates multi-tenanted research buildings, industrial plots, incubation facilities, and built-to-suit blocks. It also has Alexandria Innovation center which facilitates as an incubator.[22][23]

It has emerged as the peripheral end for technological innovation, providing sustainable nexus between the industry, research institutions, and academia. It has attracted several Global/Indian R&D majors as well as start-up companies to conduct their research activities.

IKP Knowledge Park

IKP Knowledge Park (IKP), jointly developed by ICICI Bank and the Government of Telangana (GoTS), is an intermingling of independent campuses and wet laboratory facilities.[24] It is a premier Science park spread over 200 acres of land and provides various support facilities and services to its tenant clients. It was created with the aim of creating a state-of-art ecosystem to support leading-edge innovation within the country. It promotes the advancement of technology-based entrepreneurs and small and mid-sized companies. IKP at present accommodates over 430 companies most of which are start-ups.[9][10]

The Park has a mix of ready-to-use multi-tenanted modular wet laboratory blocks (Innovation Corridors) for start-ups and established companies with in-built flexibility around some common, shared facilities, and support services, as well as developed land for customized R&D facilities. Currently, the 1,40,000 sft Innovation Corridor 1(phase I, II, and III) with 84,000 SF of wet laboratory space is operational. Around 35 acres of land has been developed with utilities for customized R&D centers. The Government of Telangana, in November 2019 has also inaugurated the Agri-innovation translation center at the newly developed Sustainability innovation center (SINC) sprawled over 1,13,000 sft area in IKP park.In keeping the overall philosophy of the Park, 7.5 acres area in the campus has been designated for developing the Medicinal garden, named "Garden of Life". IKP has set up a Life Science Incubator (LSI)  too with an incubation space of around 3,200 sft for 8 incubators to encourage and nurture start-up companies and spin-offs in pharmaceutical and biotechnology-related areas with the support of the National Science and Technology Entrepreneurship Development Board (NSTEDB). IKP Knowledge Park is a member of the International Association of Science Parks (IASP) head-quartered in Spain and also a member of the Indian Science & Technology Entrepreneurs Parks and Business Incubators Association (ISBA). There are 42 resident companies in the park so far, of which 14 have graduated and 28 are working in various e areas of chemistry, pharmaceuticals, and biotech.[25][26]

MN Park

Built in sprawling area of 300 acres including build-up facilities of around 60, 000 sft. MN (Mission Neutral) Park accommodates life sciences real estate options are grouped together. The park is dedicated to the development of Ultra-modern R&D laboratory spaces and innovation infrastructure for Life-science companies. It provides top-notch collaborative facilities and infrastructure solutions to Indian and Global organizations with key attention on turn-key pre-leased industrial assets across the value chain. The park was established in 2016, it is segregated into different towers/ office spaces with world-class facilities, which are:

  • MN Park’s Building number 450, Synergy Square 1 is a laboratory- facility designed specifically to meet the requirements of mid-sized companies in need of R&D and life-science facilities.[27]
  • MN Park, Building number  459, Synergy Square 1, has been developed as grade A office space planned for organizations to carry out backend support for their life science operations. It accommodates specialized, fully furnished 60-100 seater office spaces. GlaxoSmithkline and Novartis have occupied office spaces in it.[27]
  • MN Park, Building number 900, Synergy Square 1 is a laboratory/ manufacturing space facility designed to meet the needs of mid-scale life science companies Currently, the facility is fully leased by Laxai Life Sciences.[27]
  • MN iHub| MN Park,(Synergy Square 1 is a successful public-private partnership (PPP) model, with the government of Telangana as state support, the Department of Biotechnology (“DBT”) as center support, and the Indian Institute of Chemical Technology (IICT) as an institutional body being managed by MN as a private player. MN iHub/Biotechnology Incubation Center (BTIC) is designed, constructed, and operated to enable emerging life sciences driven companies. The center offers a wide range of services and amenities to meet the operational requirements of emerging and mid-scale life sciences driven companies. The present tenants of this facility include BE, AAP, GenomeLabs, WDB India, Chemo, Puritan Labs, Usha Biotech, Samriddhi Seeds, TCI Chemicals, AgriGenome, and Innovision. SK (GlaxoSmithKline).[28]
  • MN Park building number 2700, Synergy Square 3: This is an A-grade office space developed by Takshila Tech Paks and Incubators Pvt ltd. It offers fully equipped laboratory suites with Gold LEED Certification from the IGBC. The facility is occupied by Ashland and Alembic. It has convenient connectivity via Railway station and road transport.[27]
  • Synergy Square 4 is a 9-acre integrated park that can house companies of different fields including pharma research, new age vaccine development, CROs/ Vivariums, R&D, and Agri-research.[27]

Genome Valley Phase 3 – Karkapatla

Inaugurated in 2013 Genome Valley Phase 3 also known as The TSIIC Biotech SEZ phase 3 which is spread over 600 acres of land,[29] is located at Karkapatla village, Markook Tehsil, Siddipet District in the outskirts of Hyderabad. 19 companies had confirmed setting up their facilities here after its inauguration. Globion Global Biotech was the first company to start its operation here.[29] This SEZ at present houses companies of different fields including R&D, Biotech, Manufacturing, Biomedical and CRO.Globion Global Biotech Solutions was the first company to start its operration here. Prominent companies are Aspiro pharma, Indian Immunologicals,[30] JodasExpoim, Pulse Pharmaceuticals, RAS Lifesciences,[31] Sanmed Healthcare,[32] Sanzyme,[33] Arch Pharma, Kosher Pharmaceuticals, Vivo Biotech.[34][35][36]

Existing infrastructure

MN Park[27]

  • v 5,50,000 sft leased to R&D players
  • v Building 1800, 2700, 900, 450, 459, 5400, 9000

IKP[37]

  • v 1,40,000 sft of innovation corridor with 84,000 sft of laboratory space
  • Not for-profit entity, hence not added much space and investment over the last 10 years

Upcoming Supply

MN Park[27]

Building 3600 - 1,80,000 sft of upcoming development,  substantially committed to an existing tenant Global Pharma Giant.

Touchstone Square

  • Touchstone Square, an integrated and collaborative R&D park.
  • Under construction of 1,00,000 sft in next 3 months with potential to develop another 2,00,000 sft.

Innopolis

  • 6,00,000 sft  Nextgen Labspace under construction with potential to develop another 4,00,000 sft ▪ Phase I – 1,00,000 sft in Mar 2020.
  • Designed to support innovation programs. Innopolis provides world-class collaborative facilities and infrastructure solutions in an integrated ecosystem to Indian and multinational companies.
  • Innopolis offers leasing opportunities for wet / dry laboratory spaces, specialized office and pilot plant spaces for Life-Sciences, Chemical, Nutraceutical, Food Processing & Innovation spaces for other industries.

Genopolis

  • Planned construction of 1,30,000 sft in next 6 months.[38]
  • Designed to support innovative programs. Provides world-class collaborative facilities and infrastructure solutions in an integrated ecosystem to Indian and multinational companies.[38]

Demand

Witnessing huge demand from domestic and global Pharma and R&D Companies. MN Park has leased over 1,00,000 sft space in the last 24 months.  Existing Players looking to expand further, however, supply-side constraints.

Confirmed requirements over next few months:

Novartis: 1.5 lakh sq. ft,  Sandoz: 1.5 lakh sq. ft.

Alembic: 50,000 – 1 lakh sq. ft.

Syngene: 1-2 lakhs sq.ft.

Sai: 50,000 sq. ft.[38]

Multiple new players also looking for space including Sanofi (1 lakh sq.ft), USP (10,000 sq.ft), and others (1 lakh sq.ft.). Existing demand of c. 2 lakh sq. ft every year and growing.

Companies in Genome Valley
Clockwise from upper left: Mindspace Tech park with offices of United Health Group, Syneos Health, PAREXEL, Medtronic, Clarivate Analytics, GlobalData, IBM Watson Health, Novartis, Sanofi, Bayer, Cytel, and Celgene.[39]

Global Players

Indian Multinationals

  • Alembic Research
  • Laurus Labs
  • Biomax Life Sciences
  • Incozen Therapeutics
  • Eugia Pharma
  • Clonz Biotech
  • Issar Pharma
  • Unique Biotech
  • Ortin Biotech
  • Biomax Life Sciences
  • Laxai Avanti Life Sciences
  • Vitane Pharma
  • AAP Pharma
  • Tergene Biotech
  • Genomelabs Bio

CROs (MNCs and Indian Multinationals)

  • Envigo
  • Sai Lifesciences
  • Symphony Pharma
  • Sandor Proteomics
  • Hylasco Bio
  • Syngene[13]

Vaccine Manufacturing (MNCs and Indian Multinationals)

  • Shantha Sanofi
  • Bharat Biotech[42]
  • Indian Immunologicals
  • Biological E[28]
  • Globion
  • SAMI Labs – manufacturing

Vivarium & Similar Facilities (MNCs and Indian Multinationals)

  • RCC Laboratories
  • VIVO Biotech
  • Vimta Labs
  • Clintox

Agri Research Companies (MNCs and Indian Multinationals)

  • Adama
  • AgriGenome
  • MONSANTO
  • PIONEER Seeds
  • Samriddhi Seeds

Manufacturing:

  • Chemo
  • Nektar Therapeutics
  • Sanzyme
  • Ferring Pharma
  • Jodas Expoim
  • Laurus Labs
  • Biomax Life Sciences
  • Eugia Pharma
  • Unique Biotech
  • Vitane Pharma
  • Shantha Sanofi
  • Bharat Biotech
  • Indian Immunologicals
  • Biological E
  • Globion
  • SAMI Labs
  • Johnson & Johnson India Limited[43]
  • Bayer Biosciences[44][45]

Manufacturing with integrated research

Research and Development:

  • AMRI
  • Ashland
  • Dupont
  • Lonza
  • Novartis
  • Grace Davison
  • Daiichi
  • Daicel Chiral
  • Mylan
  • GlaxoSmithKline
  • United States Pharmacopeia
  • Alembic Research
  • Incozen - Therapeutics
  • Clonz Biotech
  • Issar Pharma
  • Ortin Biotech
  • Laxai Avanti Life Sciences AAP Pharma
  • Tergene Biotech
  • Genomelabs Bio
  • Envigo
  • Sai Lifesciences
  • Symphony Pharma
  • Sandor Proteomics
  • Hylasco Bio
  • RCC Laboratories
  • VIVO Biotech
  • Vimta Labs
  • Clintox
  • Adama
  • AgriGenome
  • Monsanto[46]
  • PIONEER Seeds
  • Samriddhi Seeds
  • Syngene

Key Manufacturing companies in Genome Valley

Chemo:

  • Spanish Conglomerate, developer and manufacturer of pharmaceutical medicine: - tablets, capsules, ointments, cough syrups, injections, eye drops.
  • Setting up its independent formulation development and manufacturing facility within the cluster.

Sanzyme:

  • Sanzyme has developed two independent campuses in Genome Valley Phase-I and Phase II, each of ~ 50,000 SF. The company is into manufacturing of Fermentation Technology, Aquaculture, Poultry, Bio-remediation and Veterinary products, in addition to Probiotics for human consumption.

Ferring Pharma:

  • Ferring Pharma is a Swiss multinational, biopharmaceutical company developing products in the fields of reproductive health, urology, gastroenterology, endocrinology, and orthopedics.
  • Planned development activity in reproductive healthcare in Genome Valley where land has been acquired and facility development is being planned.[47]

Shantha Biotechnics:

  • Shantha Biotechnics is an Indian biotechnology company based in Hyderabad. It is the first Indian company to develop, manufacture, and market recombinant human healthcare products in India. The company is a wholly-owned subsidiary of Sanofi group (French multinational)

Bharat Biotech:

  • Company has state-of-the-art manufacturing plant which is the largest of its kind in Asia-Pacific.
  • Multidimensional biotechnology company specializing in product-oriented research, development, and manufacturing of vaccines and biotherapeutics.

Biological E:

  • Biological E Limited, the first private sector biological products company in India and the first pharmaceuticals company in South India.
  • Development of Pneumococcal conjugation vaccine (PCV) and Typhoid conjugation vaccine (TCV) using CRM197 as the carrier protein.[47]

Indian Immunologicals Ltd.

  • IIL is the market leader in veterinary biologicals in India and operates one of the largest plants in the world for veterinary vaccines. IIL is also the third-largest animal health player in India with the largest selling brand – Raksha FMD Vaccine.
  • IIL is a major player in the human vaccine market in India, focusing on the pediatric and rabies vaccine segments.

Globion

  • Globion has commissioned a state-of-the-art Vaccine manufacturing facility complying with GMP standards. Globion produces a basket of Poultry Vaccines – Live and Inactivated --for Breeders, Layers, and Broilers under. The products are marketed under the brand "GlobiVac".

Unique Biotech

  • Unique Biotech Ltd (UBL) is a large scale fermentation facility for Probiotics, Enzymes, and Nutraceuticals.
  • It's dedicated to the field of discovery, development, and commercialization of innovative formulations and drugs for improved health care at an affordable cost.
  • UBL has dedicated blocks for the production of Bacillus sp, Lactobacillus sp, Bifidobacterium sp, Saccharomyces boulardii and Serratiopeptidase.[48]

Key Research & Development Companies
Clockwise from upper left:

Novartis        

  • Company’s major R&D center in India; started operations in Genome Valley in 2010.[49]

Dupont

  • DuPont Knowledge Centre (DKC); DuPont’s seventh major R&D facility outside the US.
  • The company started with a small R&D setup and later developed a dedicated R&D facility in 2007.
  • The facility houses research centers in the areas of Biotechnology, Material Research & Application, and Engineering.

GSK

  • GSK Consumer Health carry out R&D activities for New Product Development as well as method development, stability studies, and analytical development

AMRI

  • The AMRI Research Centre is the company’s first R&D center outside the US. Started in 2007 with 2 labs and 12 scientists. Established an independent 57,000 SF campus with an investment of approx. USD 0.8 Million. Proposed expansion plans to increase its existing capacity.

Mylan

  • Mylan is one of the world’s leading generics and specialty pharmaceutical companies, providing products to customers in approximately 140 countries; Expanded its operations further in India while establishing their first Biologics R&D laboratory in Genome Valley.[47]

Ashland

  • A Fortune 500 specialty chemicals company operates R&D lab and pilot plant space in Genome Valley.

Envigo

  • Envigo is a leading provider of essential non-clinical contract research, research models, animal diets, and services to the pharmaceutical, biotech, medical device, crop protection, and chemical industries, as well as universities, government, and other research organizations.

Monsanto

  • Monsanto is a publicly-traded American multinational agrochemical and agricultural biotechnology corporation. Monsanto is a leading producer of genetically engineered (GE) seed and Roundup, a glyphosate-based herbicide.[12]

Social infrastructure
  • Singapore-based Jurong Consultants India Pvt Ltd have designed a master-plan to give a face-lift to the city. The Government of Telangana have roped the firm in 2018 for this purpose with the aim to strengthen the infrastructure of the region.[50][51]
  • This face-lifting has given Hyderabad the impetus in social infrastructure which include
  • The 159 km long outer ring road (ORR), an orbital linkage connecting the existing arterial roads and various nodes of the city.
  • The 11.5 km long P V Narasimha Rao Elevated Expressway in Hyderabad. Which is considered as Asia’s longest elevated expressway. It connects the heart of the city to the Hyderabad International Airport.
  • The 43 km long Multi Modal Transport System (MMTS), a dedicated city rail service, connects different parts of Hyderabad, commuting over 70,000 people daily.
  • A 66 km long Hyderabad Metro project is being initiated. The metro rail would be connected with the roads and the MMTS networks, thus creating an integrated transport hub.
  • Hyderabad Metropolitan Water Supply & Sewerage Board (HMWSSB) designed the INR 1,000 crore Krishna River project to supply 90 million gallons of water every day to the twin cities of Hyderabad and Secunderabad.[52]

Connectivity
  • Rajiv Highway (SH-1) – 1 km
  • Hospitals – 1 km
  • Upcoming 80 Bed Multi Specialty Hospital – 3 km
  • ORR – 13 km
  • JBS Bus Station – 32 km
  • Secunderabad Railway Station – 34 km
  • International Airport – 85 km

Others

See also

References
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