Haplogroup R-DF27

Haplogroup R-DF27
Possible time of origin	4,200 years BP
Possible place of origin	Central Europe
Ancestor	R-M269, R-L151, P312, Z40481, ZZ11
Defining mutations	R-M167, R-M153
Highest frequencies	Gallo-Iberians (Basques, Catalans, Galicians, Asturians, Gascons, Béarnese and others)

In human genetics, Haplogroup R-DF27 (R1b1a2a1a2a) is a Y-chromosome haplogroup which is a subdivision of haplogroup R-M269 (more specifically, its subclade R-) defined by the presence of the marker DF27 (also known as S250). Along with R-U152 and R-L21, the lineage is to a significant extent associated with Proto-Celtic, Celtic and later Celtiberian movements.

It arose comparatively recently, after the beginning of the European Bronze Age, and is mostly prevalent in the population of the Pyrenees region. The regions where it has been mostly found are Basque Country, Navarre, Asturias, Galicia, Portugal, Aragon, Catalonia, Pyrénées-Atlantiques as well as a some presence in Great Britain and Ireland, though it has been found in smaller quantities as far away as Germany and Poland.

Specific subclades of DF27 have been associated with specific groups of people, for example R-M167 is associated with the Catalans and R-M153 is associated with the Basques.[1]

Genetic testing

The technology to test for DF27 was developed by Thomas Krahn, then of Family Tree DNA. This marker was discovered to exist among people who had taken part in the Human Genome Diversity Project. Richard A. Rocca made a pioneering study of DF27, which was published in 2012 in the article Discovery of Western European R1b1a2 Y Chromosome Variants in 1000 Genomes Project Data, in the peer-reviewed journal PLOS Biology. He based his study on 208 people who had tested as R-M269 and were from Great Britain, Tuscany (Italy), Spain, Finland, Utah (United States) and Latin American (Colombia, Puerto Rico, etc).[2]

Distribution

According to a 2017 article published in Springer Nature entitled, Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ, DF27 was found in frequences of 40% in the general population of the Iberian Peninsula and in particular spikes at 70% among the Basques. Overall in France it accounts for between 6–20% of the population but has a high level in the Pyrenees area. It is estimated to have developed around 4,200 years ago in north-eastern Prehistoric Iberia as the Neolithic made way for the Atlantic Bronze Age. The DF27 subgroups correspond closely to the various pre-Roman kingdoms formed by the Celtiberians.[3]

Subclades

Y-DNA R-DF27 subclades

DF27*
Z195
ZZ12_1
SK1907

Y-DNA backbone tree

Phylogenetic tree of human Y-chromosome DNA haplogroups [χ 1][χ 2]

A1b

A1b1

F1

F2

F3

GHIJK

I

J

LT [χ 5]

K2 [χ 6]

L

T

K2a [χ 7]

K2b [χ 8]

K2c

K2d

K2e [χ 9]

K-M2313 [χ 10]

K2b1 [χ 11]

P [χ 12]

NO

S [χ 13]

M [χ 14]

P1

P2

Footnotes

Van Oven M, Van Geystelen A, Kayser M, Decorte R, Larmuseau HD (2014). "Seeing the wood for the trees: a minimal reference phylogeny for the human Y chromosome". Human Mutation. 35 (2): 187–91. doi:10.1002/humu.22468. PMID 24166809.
International Society of Genetic Genealogy (ISOGG; 2015), Y-DNA Haplogroup Tree 2015. (Access date: 1 February 2015.)
Haplogroup A0-T is also known as A-L1085 (and previously as A0'1'2'3'4).
Haplogroup A1 is also known as A1'2'3'4.
Haplogroup LT (L298/P326) is also known as Haplogroup K1.
Between 2002 and 2008, Haplogroup T-M184 was known as "Haplogroup K2". That name has since been re-assigned to K-M526, the sibling of Haplogroup LT.
Haplogroup K2a (M2308) and its primary subclade K-M2313 were separated from Haplogroup NO (F549) in 2016. (This followed the publication of: Poznik GD, Xue Y, Mendez FL, et al. (2016). "Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences". Nature Genetics. 48 (6): 593–9. doi:10.1038/ng.3559. PMC 4884158. PMID 27111036. In the past, other haplogroups, including NO (M214) and K2e had also been identified with the name "K2a".
Haplogroup K2b (M1221/P331/PF5911) is also known as Haplogroup MPS.
Haplogroup K2e (K-M147) was previously known as "Haplogroup X" and "K2a" (but is a sibling subclade of the present K2a).
K-M2313*, which as yet has no phylogenetic name, has been documented in two living individuals, who have ethnic ties to India and South East Asia. In addition, K-Y28299, which appears to be a primary branch of K-M2313, has been found in three living individuals from India. See: Poznik op. cit.; YFull YTree v5.08, 2017, "K-M2335", and; PhyloTree, 2017, "Details of the Y-SNP markers included in the minimal Y tree" (Access date of these pages: 9 December 2017)
Haplogroup K2b1 (P397/P399) is also known as Haplogroup MS, but has a broader and more complex internal structure.
Haplogroup P (P295) is also klnown as K2b2.
Haplogroup S, as of 2017, is also known as K2b1a. (Previously the name Haplogroup S was assigned to K2b1a4.)
Haplogroup M, as of 2017, is also known as K2b1b. (Previously the name Haplogroup M was assigned to K2b1d.)

References

"Evidence of Pre-Roman Tribal Genetic Structure in Basques from Uniparentally Inherited Markers". Oxford Journals. 26 January 2018.
"Discovery of Western European R1b1a2 Y Chromosome Variants in 1000 Genomes Project Data: An Online Community Approach". PLOS Biology. 26 January 2018. doi:10.1371/journal.pone.0041634.
"Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ". Springer Nature. 26 January 2018.

Bibliography

Manco, Jean (2015). Ancestral Journeys: The Peopling of Europe from the First Venturers to the Vikings. Thames and Hudson. ISBN 978-0500292075.CS1 maint: ref=harv (link)

External links

R-DF27/S250 at The Big Tree
R DF27 and Subclades at Family Tree DNA
R1b-DF27.com

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[vanOven2014-4] Van Oven M, Van Geystelen A, Kayser M, Decorte R, Larmuseau HD (2014). "Seeing the wood for the trees: a minimal reference phylogeny for the human Y chromosome". Human Mutation. 35 (2): 187–91. doi:10.1002/humu.22468. PMID 24166809.

[ISOGG2015-5] International Society of Genetic Genealogy (ISOGG; 2015), Y-DNA Haplogroup Tree 2015. (Access date: 1 February 2015.)

[A0-T-6] Haplogroup A0-T is also known as A-L1085 (and previously as A0'1'2'3'4).

[A1-7] Haplogroup A1 is also known as A1'2'3'4.

[LT-8] Haplogroup LT (L298/P326) is also known as Haplogroup K1.

[K2-9] Between 2002 and 2008, Haplogroup T-M184 was known as "Haplogroup K2". That name has since been re-assigned to K-M526, the sibling of Haplogroup LT.

[K2a-10] Haplogroup K2a (M2308) and its primary subclade K-M2313 were separated from Haplogroup NO (F549) in 2016. (This followed the publication of: Poznik GD, Xue Y, Mendez FL, et al. (2016). "Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences". Nature Genetics. 48 (6): 593–9. doi:10.1038/ng.3559. PMC 4884158. PMID 27111036. In the past, other haplogroups, including NO (M214) and K2e had also been identified with the name "K2a".

[K2b-11] Haplogroup K2b (M1221/P331/PF5911) is also known as Haplogroup MPS.

[K2e-12] Haplogroup K2e (K-M147) was previously known as "Haplogroup X" and "K2a" (but is a sibling subclade of the present K2a).

[K-M2313-13] K-M2313*, which as yet has no phylogenetic name, has been documented in two living individuals, who have ethnic ties to India and South East Asia. In addition, K-Y28299, which appears to be a primary branch of K-M2313, has been found in three living individuals from India. See: Poznik op. cit.; YFull YTree v5.08, 2017, "K-M2335", and; PhyloTree, 2017, "Details of the Y-SNP markers included in the minimal Y tree" (Access date of these pages: 9 December 2017)

[K2b1-14] Haplogroup K2b1 (P397/P399) is also known as Haplogroup MS, but has a broader and more complex internal structure.

[P-15] Haplogroup P (P295) is also klnown as K2b2.

[S-16] Haplogroup S, as of 2017, is also known as K2b1a. (Previously the name Haplogroup S was assigned to K2b1a4.)

[M-17] Haplogroup M, as of 2017, is also known as K2b1b. (Previously the name Haplogroup M was assigned to K2b1d.)

[1] "Evidence of Pre-Roman Tribal Genetic Structure in Basques from Uniparentally Inherited Markers". Oxford Journals. 26 January 2018.

[2] "Discovery of Western European R1b1a2 Y Chromosome Variants in 1000 Genomes Project Data: An Online Community Approach". PLOS Biology. 26 January 2018. doi:10.1371/journal.pone.0041634.

[3] "Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ". Springer Nature. 26 January 2018.