KIF3A
Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene.[5][6]
Function
KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification.[7] This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein (KAP3), and it transports protein complexes, nucleic acids and organelles towards the "plus" ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intra-flagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips.[8] This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.[9]
References
- GRCh38: Ensembl release 89: ENSG00000131437 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000018395 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Whitehead JL, Wang SY, Bost-Usinger L, Hoang E, Frazer KA, Burnside B (November 1999). "Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina". Exp. Eye Res. 69 (5): 491–503. doi:10.1006/exer.1999.0724. PMID 10548469.
- "Entrez Gene: KIF3A kinesin family member 3A".
- Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM (November 1993). "Novel heterotrimeric kinesin-related protein purified from sea urchin eggs". Nature. 366 (6452): 268–70. doi:10.1038/366268a0. PMID 8232586. S2CID 4367715.
- Rosenbaum JL, Witman GB (November 2002). "Intraflagellar transport". Nat. Rev. Mol. Cell Biol. 3 (11): 813–25. doi:10.1038/nrm952. PMID 12415299. S2CID 12130216.
- Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N (December 1998). "Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein". Cell. 95 (6): 829–37. doi:10.1016/S0092-8674(00)81705-5. PMID 9865700. S2CID 62805329.
- Nagata K, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
Further reading
- Aizawa H, Sekine Y, Takemura R, et al. (1992). "Kinesin family in murine central nervous system". J. Cell Biol. 119 (5): 1287–96. doi:10.1083/jcb.119.5.1287. PMC 2289715. PMID 1447303.
- Yamazaki H, Nakata T, Okada Y, Hirokawa N (1995). "KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport". J. Cell Biol. 130 (6): 1387–99. doi:10.1083/jcb.130.6.1387. PMC 2120571. PMID 7559760.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
- Yang Z, Goldstein LS (1998). "Characterization of the KIF3C neural kinesin-like motor from mouse". Mol. Biol. Cell. 9 (2): 249–61. doi:10.1091/mbc.9.2.249. PMC 25248. PMID 9450952.
- Shimizu K, Shirataki H, Honda T, et al. (1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide". J. Biol. Chem. 273 (12): 6591–4. doi:10.1074/jbc.273.12.6591. PMID 9506951.
- Hasegawa T, Yagi A, Isobe K (2000). "Interaction between GADD34 and kinesin superfamily, KIF3A". Biochem. Biophys. Res. Commun. 267 (2): 593–6. doi:10.1006/bbrc.1999.1991. PMID 10631107.
- Jimbo T, Kawasaki Y, Koyama R, et al. (2002). "Identification of a link between the tumour suppressor APC and the kinesin superfamily". Nat. Cell Biol. 4 (4): 323–7. doi:10.1038/ncb779. PMID 11912492. S2CID 10745049.
- Aronov S, Aranda G, Behar L, Ginzburg I (2003). "Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules". J. Cell Sci. 115 (Pt 19): 3817–27. doi:10.1242/jcs.00058. PMID 12235292.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
- Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Brown CL, Maier KC, Stauber T, et al. (2006). "Kinesin-2 is a motor for late endosomes and lysosomes". Traffic. 6 (12): 1114–24. doi:10.1111/j.1600-0854.2005.00347.x. PMID 16262723. S2CID 25560378.
- Haraguchi K, Hayashi T, Jimbo T, et al. (2006). "Role of the kinesin-2 family protein, KIF3, during mitosis". J. Biol. Chem. 281 (7): 4094–9. doi:10.1074/jbc.M507028200. PMID 16298999.
- Camargo LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry. 12 (1): 74–86. doi:10.1038/sj.mp.4001880. PMID 17043677.
- Pantelidou M, Zographos SE, Lederer CW, et al. (2007). "Differential expression of molecular motors in the motor cortex of sporadic ALS". Neurobiol. Dis. 26 (3): 577–89. doi:10.1016/j.nbd.2007.02.005. PMID 17418584. S2CID 2838469.
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