MAP3K10

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.[5][6][7]

MAP3K10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAP3K10, MEKK10, MLK2, MST, mitogen-activated protein kinase kinase kinase 10
External IDsOMIM: 600137 MGI: 1346879 HomoloGene: 1834 GeneCards: MAP3K10
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.2Start40,191,426 bp[1]
End40,215,575 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4294

269881

Ensembl

ENSG00000130758

ENSMUSG00000040390

UniProt

Q02779

Q66L42

RefSeq (mRNA)

NM_002446

NM_001081292
NM_001290528

RefSeq (protein)

NP_002437

NP_001277457

Location (UCSC)Chr 19: 40.19 – 40.22 MbChr 7: 27.66 – 27.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phosphorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.[7]

Interactions

MAP3K10 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000130758 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040390 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR, Simpson RJ (February 1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur J Biochem. 234 (2): 492–500. doi:10.1111/j.1432-1033.1995.492_b.x. PMID 8536694.
  6. Katoh M, Hirai M, Sugimura T, Terada M (May 1995). "Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain". Oncogene. 10 (7): 1447–51. PMID 7731697.
  7. "Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10".
  8. Nagata Ki, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
  9. Liu YF, Dorow D, Marshall J (June 2000). "Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin". J. Biol. Chem. 275 (25): 19035–40. doi:10.1074/jbc.C000180200. PMID 10801775.
  10. Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (October 1999). "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245–54. doi:10.1128/mcb.19.10.7245. PMC 84717. PMID 10490659.
  11. Marcora E, Gowan K, Lee JE (August 2003). "Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2". Proc. Natl. Acad. Sci. U.S.A. 100 (16): 9578–83. doi:10.1073/pnas.1133382100. PMC 170960. PMID 12881483.

Further reading


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