Katie Ewer

Katie Jane Ewer is a British cellular immunologist. She is an associate professor and Senior Immunologist at the Edward Jenner Institute for Vaccine Research and Nuffield Department of Clinical Medicine.

Katie Ewer
Academic background
EducationPhD, Immunology, 2004, Open University
ThesisRelationships between tuberculosis exposure, ex vivo antigen-specific T cell responses, and delayed type hypersensitivity in point-source outbreaks. (2004)
Academic work
InstitutionsUniversity of Oxford

Early life and education

Growing up, Ewer was interested in pursuing a career in biology for she was "fascinated by seemingly endless processes that occur in our cells and organs every second of our lives without us knowing about it."[1] She earned an undergraduate degree in biomedical science, which included a year of microbiology training,[2] before being rejected from medical school.[1] She began working as a biomedical scientist at the microbiology department of the John Radcliffe Hospital in 2000.[3] Having already found a liking for microbiology specializing in infectious diseases, she chose to pursue a PhD on the immunology of tuberculosis (TB).[2] She earned her PhD through Open University as a result of her research with Ajit Lalvani on novel diagnostic tools for tuberculosis.[3]

Career

Upon earning her PhD, Ewer joined the UK's Animal and Plant Health Agency where she studied the successfulness of TB vaccines in cattle and managed the roll-out of interferon-gamma-based diagnosis for bovine TB in the UK herd for the Department for Environment, Food and Rural Affairs.[3] In this role, she also co-published Diagnosis of tuberculosis in South African children with a T cell-based assay: a prospective cohort study with Susan Liebeschuetz.[4]

In 2008, Ewer became a Senior Immunologist at Oxford University's Edward Jenner Institute for Vaccine Research.[3] While there, she continued to study the effects of TB on populations and led clinical trials in an effort to discover a vaccine for Ebola.[5] The aim of her research was to define vaccine-induced immunological parameters that correlate with protection from malaria and understand why vaccines do not always work as well as expected.[6] During the COVID-19 pandemic, she led clinical controlled trials in an effort to find a vaccine, which was publish in a 2020 study titled Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial.[7]

References
  1. Stokel-Walker, Chris (10 April 2020). "When Will There Be A Coronavirus Vaccine?". esquire.com. Esquire. Retrieved 21 July 2020.
  2. Todd, Benjamin (20 November 2013). "Interview with malaria vaccine researcher Katie Ewer". 80000hours.org. Retrieved 21 July 2020.
  3. "Katie Ewer". conted.ox.ac.uk. Retrieved 21 July 2020.
  4. Liebeschuetz, Susan; Bamber, Sheila; Ewer, Katie; Deeks, Jonathan; Pathan, Ansar A.; Lalvani, Ajit (10 December 2004). "Diagnosis of tuberculosis in South African children with a T cell-based assay: a prospective cohort study". The Lancet. 364 (9452): 2196–2203. doi:10.1016/S0140-6736(04)17592-2. PMID 15610806. S2CID 35679204. Retrieved 21 July 2020.
  5. "Katie Ewer Senior Immunologist: Malaria and Ebola Vaccine Trials". ndm.ox.ac.uk. Retrieved 21 July 2020.
  6. "Katie Ewer ASSOCIATE PROFESSOR". medsci.ox.ac.uk. Retrieved 21 July 2020.
  7. Folegatti, Pedro M.; Ewer, Katie J.; et al. (20 July 2020). "Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial". The Lancet. 396 (10249): 467–478. doi:10.1016/S0140-6736(20)31604-4. PMC 7445431. PMID 32702298. Retrieved 21 July 2020.
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