Kolbe electrolysis

The Kolbe electrolysis or Kolbe reaction is an organic reaction named after Hermann Kolbe.[1] The Kolbe reaction is formally a decarboxylative dimerisation of two carboxylic acids (or carboxylate ions). The overall reaction is:

If a mixture of two different carboxylates are used, all combinations of them are generally seen as the organic product structures:

3 R₁COO⁻ + 3 R₂COO⁻ → R₁−R₁ + R₁−R₂ + R₂−R₂ + 6 CO₂ + 6 e⁻

The reaction mechanism involves a two-stage radical process: electrochemical decarboxylation gives a radical intermediate, which combine to form a covalent bond.[2] As an example, electrolysis of acetic acid yields ethane and carbon dioxide:

CH₃COOH → CH₃COO⁻ → CH₃COO· → CH₃· + CO₂

2CH₃· → CH₃CH₃

Another example is the synthesis of 2,7-dimethyl-2,7-dinitrooctane from 4-methyl-4-nitrovaleric acid:[3]