Meri Aashiqui Tum Se Hi

Ranveer is a successful business tycoon under the name of RV. Ishaani's family is now poor facing a shortage of money due to Harshad's death and fighting for their former mansion when it is put up on auction. Ranveer buys it when they lose their case that would have given them all their money back.

When Ishaani's fiancé Chirag Mehta finds out, he abandons Ishaani on their wedding day when he realizes Ishaani will no longer be wealthy. Ranveer still madly in love with Ishani aims to protect her from Chirag's selfish motives. He comes to know that the case failed because of his mother Amba. As Ishaani is alone on her wedding day, he volunteers to marry Ishaani to save her family even though he had previously committed to marry Ritika, the wealthy daughter of jeweler Sanjeev Zaaveri.

Ranveer is happy that his dream came true and can finally be happy with his childhood love Ishaani. However, she still does not love him and only marries him after her mother Falguni begs her to realize that Ranveer is the only person who can save her family from poverty.

Ranveer's one sided love and respect for Ishaani makes her realize that they could go back to being friends. Chirag returns after leaving Ishaani at her wedding. Wanting revenge from Ranveer, he tries in making Ishaani believe Ranveer is responsible for Harshad's demise.

Ishaani refuses to believe Chirag but he uses his many resources to convince her that Ranveer killed Harshad. Heartbroken, Ishaani spends time with Chirag on Karwa Chauth trying to find more evidence. Chirag runs car over Shenela with Ishaani's car and Shanela's brother vows to take revenge for her condition as she ends up in coma.

Shenela wakes up and tries to tell her brother that Chirag was trying to destroy Ranveer. However, he mistakes Ranveer to be the killer.

Ishaani finally realizes Ranveer's innocence. Chirag tries to rape her and reveals how Ranveer had been saving her from every problem and he was not Harshad's killer. In the ensuing scuffle, Ishaani gets hurt but manages to run away. She goes to Ranveer to complete her fast believing him and hoping to reunite.

At first Ranveer doesn't believe that Ishaani cheated on him. But when he is sent fake intimate pictures of them, made by Chirag, he gets heartbroken and goes to confront Ishaani. Shenela's brother shoots Ranveer who is rushed to the hospital. Ishaani expresses her love for Ranveer as he slips into coma.

Ranveer wakes up but reveals he has lost trust in Ishaani and now hates her. She plans to win back Ranveer's love, fighting hurdles along the way. As Ranveer discovers Chirag's intentions, he reunites with Ishaani and decides to make their relationship public on Ritika and Sharman's Sangeet ceremony.

Sanjeev dies after knowing about Ritika's pregnancy and Sharman calls off the wedding. Chirag and Ranveer fight in a secluded place while Ishaani follows them and is shocked to see Chirag's dead body. Believing Ranveer had murdered him, she takes the blame and goes to jail, sentenced to be executed.

Assumed dead, Ishaani is saved by Ranveer's friend Shikhar Mehra, a lawyer. Ritika lives in the Vaghela Mansion as Ranveer's wife for her unborn child. Ishaani begins to live in Shikhar's house. He falls in love with her. Eventually, everyone gets to know that Ishaani is alive.

Ranveer tells Shikhar that Ishaani is still his wife. But believing that he is the father of Ritika's child and happy in his life, Ishaani lies to him that she never loved him back and would rather die than reuniting with him. When Shikhar proposes, Ishaani accepts his proposal and announces her wedding with him.

Ranveer makes Shikhar realize that Ishaani is not right for him and she is only using him for his money. Ishaani discloses to Shikhar that she is marrying him to move on and he understands her. As Ranveer discourages Ishaani, she tells him not to meddle and expresses hatred toward him.

On her wedding with Shikhar, Ishaani learns that Ritika killed Chirag and Falguni as well as that her child's father is Chirag. As Ritika finds out, she stabs Ishaani and leaves her to die. Shikhar rescues Ishaani and takes her to a hospital.

Vowing to protect Ranveer from Ritika's clutches, Ishaani stops their wedding presenting evidence that their divorce wasn't finalized yet.. Having no evidence, Ishaani doesn't expose her but fakes a memory loss and tries many ways to make Ranveer trust her, to which he refuses. Ritika sends a man to kill Ishaani who shoots herself.

Ritika loses her unborn child and blames Ishaani. When Ranveer inquires with the killer about it, he also gives the same explanation about Ishaani being the contractor. She tries her best to make Ranveer believe about Ritika's true motives. However, he throws Ishaani out of his house.

Ishaani comes back. But Ranveer blackmails her for divorce. Ishaani jumps into a river to prevent Ranveer from committing suicide. Following this, Ranveer starts believing her and traps Ritika in his own plan. She is finally exposed and given a jail sentence.

Ranveer rushes to Ishaani who goes to the railway station with her family leaving to Baroda. They finally express their feelings and reunite.

However, it is revealed that Ranveer had a twin brother named Milan, whom his parents were forced to give up for adoption when they were in dire need of money after Ranveer had met with a serious accident during their childhood. Milan hates Ranveer and vows to destroy him and snatch everything Ranveer holds dear. On their wedding night, Milan kidnaps Ranveer and enters into Vaghela Mansion posing as him. However, Ishaani starts to notice his changing behavior immediately. With time, Milan falls in love with her and despite creating a lot of hurdles when he realizes he cannot take Ranveer's place in Ishaani's life, he injects Ranveer's face with Virus D that will degrade his face. He also kills Sharman and makes a video of confessing to his crime under Ranveer's name and commits suicide.

Ritika comes out of the jail to take revenge from Ishaani along with Nirbhay Singh Ahlawat who thinks Ranveer is responsible for his wife's death and his sister Naina being paralyzed. Nirbhay is the owner of the lab that makes the antidote of Virus D and puts a condition before Ishaani that he'll submit all the evidence that will prove Ranveer innocent in court and cure him but Ishaani will have to make Ranveer hate him and leave from his life. Ishaani agrees and Ranveer gets freed. However, Ishaani misbehaves with him and his parents and gives him divorce and pretends to be Nirbhay's wife.

Nirbhay keeps torturing Ishaani to exact his revenge from Ranveer. Ranveer comes to take revenge from Ishaani but still hopes that Ishaani had a reason to do everything and she was still in love with him. Naina falls in love with Ranveer and he accepts the proposal to spite Ishaani. During the function he notices Ritika and gets confident about some conspiracy going behind his back. He confronts Ishaani several times and finally she accepts she had always been in love with him and the two consummates their marriage on their wedding anniversary. Ranveer gathers evidences and proves to Nirbhay that he didn't kill his wife Pooja. It is revealed that Pooja's family members had planned the accident to kill Nirbhay as they hated him and wanted his property. Enraged, Nirbhay throws them out and apologiges to Ishaani and Ranveer. The two finally unite and happily embrace each other.