Ned D. Heindel

Ned D. Heindel (September 4, 1937) is an American chemist. He is the Howard S. Bunn Distinguished Professor Emeritus of Chemistry at Lehigh University, where he continues to do research.[2] Heindel also works as a medical research consultant.[3][1][4] Heindel's research focuses on diagnostic and therapeutic drug development. He served as president of the American Chemical Society in 1994,[5] and has twice chaired the ACS Division for the History of Chemistry.[6]

Ned D. Heindel
Born (1937-09-04) September 4, 1937[1]
Red Lion, York County, Pennsylvania[1]
NationalityUnited States
Board member ofPresident of the American Chemical Society
AwardsACS fellow
Academic background
Alma materLebanon Valley College, University of Delaware
Academic work
DisciplineChemistry
Sub-disciplineOrganic chemistry, Medicinal chemistry
InstitutionsLehigh University

Early life

Ned Duane Heindel was born on September 4, l937 in Red Lion, York County, Pennsylvania to Mr. and Mrs. Penrose H. Heindel.[6][7] He earned a B.S. in chemistry from Lebanon Valley College (1959), and a Master's degree (1961) and Ph.D. (1963) from the University of Delaware,[8] where he worked with William A. Mosher.[2] He did postdoctoral work at Princeton University in 1964[9] with Edward C. Taylor.[2]

Career

After teaching briefly at Ohio University and Marshall University Heindel joined the faculty at Lehigh University in 1966. He became a full professor by 1973,[2] and was named the Howard S. Bunn Distinguished Professor of Organic Chemistry in 1976.[1][10][7]

Heindel also served as a Visiting Professor of Radiation Oncology at Hahnemann University Hospital from 1971-2006, and as Director of the Center for Health Sciences at Lehigh University from 1980-1987. He helped to establish the Lehigh-Hahnemann Cooperative Medical Education Program from 1992-2017 and was involved in Lehigh's Distance Education program.[2]

Heindel became professor emeritus in 2018. He continues to do research (e.g. healing burn wounds[11]) and works as a medical research consultant.[2]

Science

Heindel's research focuses on diagnostic and therapeutic drug development, including the areas of cancer research, nuclear medicine, diagnostic radioactive pharmaceuticals,[1][12][13] chemotherapeutics and tumor-associated monoclonal antibodies.[14] He has applied for at least 20 patents, with 14 issued.[2][9][15] He has published more than 260 papers.[2][16] A number of candidate pharmaceuticals from his lab have reached advanced animal trials.[17][18]

Heindel has shown that psoralens and coumarins can be useful as photoactivated inhibitors of epidermal growth factor.[19][20][21][22] Photosensitizers are used to treat epidermal proliferation, psoriasis and vitiligo. Heindel's lab has identified a new structural family of organic molecules which perform as light-activated anti-cancer compounds. After activation by ultraviolet light, lipophilic dipyranone (NDH2476) was found to inhibit abnormal Keratinocyte growth with an IC50 of 9 nanomolar concentration. NDH2476 acts through initial intercalation into DNA and when irradiated, “nicks” the polynucleotide and prevents subsequent unwinding. Gem di-methylation, double bond hydrogenation, or non-linear, angular geometry to the dipyranone greatly reduced or even eliminated the photo-cytotoxicity.[23]

Heindel is one of the principal investigators in Project CounterACT-Rutgers, studying antidotes to sulfur mustard gas poisoning.[24][9] Heindel's lab has developed an indomethacin prodrug, NDH4338, designed for use as a wound-healing accelerant for vesicant-triggered skin lesions. The drug is a trifunctional pharmaceutical composed of covalently linked inhibitors of COX-2, acetylcholinesterase, and induced nitric oxide synthase which can be released in vivo from the parent molecule. It has been tested on rodents pre-exposed to chloroethyl ethyl sulfide, nitrogen mustard, and sulfur mustard and has shown a marked acceleration of wound healing. While NDH4338 has several mechanisms of action, a principle one is suppression of mast cell degranulation in skin.[18][25]

Hydroxamate compounds developed by Heindel's lab have been found to enhance corneal wound healing after mustard exposure. Compounds studied include olvanil OH (NDH4409) and retro olvanil 8 (NDH4417). Hydroxamates reduced the activity of ADAM17 and matrix metalloproteinases (MMPs), and attenuated expression of EMMPRIN, a tumor cell surface inducer of MMPs. This resulted in less epithelial sloughing, improved protection of the basement membrane zone, and better epithelial-stromal integrity after injury.[26]

Heindel serves on the Board of Directors of the Pennsylvania Drug Discovery Institute,[27] and the Scientific Advisory Board of Azevan Pharmaceuticals, Inc.[4]

Heindel has held a number of positions in the American Chemical Society (ACS), since first becoming a board member in 1985.[5] In 1994, Heindel served as President of the ACS.[28][29] In 2009 Heindel was named an ACS Fellow.[30]

History

Heindel has served on the Board of Directors of the National Foundation for History of Chemistry,[31] and has twice been chairperson of the ACS Division of the History of Chemistry.[6] Heindel has been credited with chairing a task force formed by the ACS in 1979 to consider the creation of a national center for the history of chemistry,[32] but he himself credits John H. Wotiz with that chairmanship.[33] In December 1981 the ACS approved the establishment of the Center for the History of Chemistry in Philadelphia.[32][34] He was a contributor to a NOVA program about Percy Julian, “Forgotten Genius”, which aired in 2007.[2]

Heindel has written both papers and books relating history and chemistry. Among his publications he has examined "The Professionalization of American Chemistry: How the German Ph.D. Model Crossed the Atlantic",[35] and the careers of early photochemists such as Giacomo Ciamician.[36]

Another area of interest is the medicinal chemistry and folk-healing techniques of the Pennsylvania Dutch. The Nineteenth Century Horse Doctor: A Pennsylvania Dutchman’s Practical Guide to Treating Horses recognized the essential role of the horse in pre-industrial North American farming. Heindel and Robert D. Rapp translate and examine recipes in 19th century books of veterinary practice, or "Pferdartz", from the Moravian and the Pennsylvania Dutch traditions. Folk medicine cures ranged from herbs, minerals, poultices, and bleeding to incantations.[37][38]

In Hexenkopf, History, Healing and Hexerei, he examines traditions of both white and black magic in the Wilhelm and Saylor families of Bucks County, Pennsylvania. Healers such as Johann Peter Seilor[39] and Emanuel Wilhelm used tonics, personalized prescriptions and manipulations to treat sickness and fight off evil in the tradition of white magic or "Braucherei". Modern pharmaceutical science has examined the use of some of their treatments such as poke root and mayapple root.[40] Traditions of black magic have focused on Hexenkopf Rock.[41][42][43]

Heindel and his wife Linda (Heefner) Heindel are active in historical groups in the Lehigh Valley[44] and frequently contribute to Pennsylvania Folklife Magazine.[45] Heindel has lectured on social relationships between Europeans, Lenni Lenape, and Shawnee in the Durham area in the 1700s. He is interested in the work of the Buckwampum Historical and Literary Society,[46] a group that met from 1888 to 1903. Most were amateurs but archaeologist Henry Mercer was also a member. The group conducted several digs in Bucks County, Pennsylvania and Northampton County, Pennsylvania.[47]

Land conservation

Over a 50 year period, Ned and Linda Heindel have purchased and preserved 128 acres of "forest, bogs and meadows" around the stone farmhouse in which they live, in Williams Township, Northampton County, Pennsylvania. The hilly area includes stands of ash, poplar and oak trees, wild azalea, freshwater springs and Hexenkopf Rock, a ridge of exposed Precambrian stone.[48] Linda Heindel serves as the secretary of the Land Preservation Board of Williams Township, Northampton County, PA.[49]

As of August 2014, a consortium of energy companies announced plans to build the PennEast Pipeline to carry natural gas from the Marcellus Shale in Pennsylvania into New Jersey. Ned and Linda Heindel are among residents who would be affected.[48]

Beginning on February 6, 2018, the PennEast Pipeline Co. has filed eminent domain notices in federal court to take possession of rights of way on the lands of those who have not agreed to the pipeline.[50] Those who received eminent domain notices include at least 129 New Jersey landowners[51] and 50 Pennsylvania landowners,[52] among them the Heindels.[53] The Heindels are active opponents of the proposed pipeline and the attempted seizure of their land under eminent domain.[54][48][53]

Awards
  • 2011, Hillman Faculty Award, Lehigh University, for educational and research achievements [55][27]
  • 2009, Fellow, American Chemical Society[30]
  • 2002, Ben Franklin Partnership Award for Corporate Assistance[56]
  • 1997, Henry Hill Award for Achievements in Medicinal Chemistry, NOBCChE[57]
  • 1996, Harry and Carol Mosher Award for Contributions to Chemistry, ACS[58]
  • 1989, Brady Cancer Achievement Award, Brady Cancer Research Foundation, for research in tumor-imaging radiopharmaceuticals[1][27]
  • 1978, Briody Award[10]
  • 1969, Robinson Award[10]

References
  1. American men & women of science, 1995-96 : a biographical directory of today's leaders in physical, biological and related sciences. 3 (19th ed.). New Providence, New Jersey: R. R. Bowker. 1996. pp. 739–740. ISBN 978-0835234665.
  2. "Transitioning into a renewed focus on excellence" (PDF). MUDD in your eye (Fall). Lehigh University, Department of Chemistry. 2018. pp. 4–5, 18. Retrieved 5 October 2018.
  3. Finn, John (1 October 2015). "Helen Murray Free Lectures Feature Pharmaceutical Expert". Wooster.
  4. "Ned Heindel Ph.D." Bloomberg. Retrieved 10 October 2017.
  5. Carpenter, Ernest (23 November 1992). "Ned Heindel chosen ACS president-elect". Chemical & Engineering News. 70 (47): 5–6. doi:10.1021/cen-v070n047.p005a.
  6. "Biography: Ned Heindel". Lehigh University. Retrieved 10 October 2017.
  7. "Awarded Chemistry Recognition DR. NED D. HEINDEL RED LION". York Daily Record from York, Pennsylvania. June 2, 1976. p. 6. Retrieved 10 October 2017.
  8. Kaufman, Ron (January 11, 1993). "People: Lehigh Professor Is Named Chemical Society's President-Elect". The Scientist. Retrieved 10 October 2017.
  9. Committee on Promoting Safe and Secure Chemical Management in Developing Countries, Board on Chemical Sciences and Technology, Division on Earth and Life Studies, National Research Council of the National Academies (2010). Promoting chemical laboratory safety and security in developing countries. Washington, D.C.: National Academies Press. p. 75. ISBN 978-0309150415. Retrieved 10 October 2017.CS1 maint: multiple names: authors list (link)
  10. Henderson, Andrea Kovacs, ed. (2010). "Heindel, Ned Duane". American Men & Women of Science: A Biographical Directory of Today's Leaders in Physical, Biological, and Related Sciences. 3 (28th ed.). Detroit: Gale. p. 701. Retrieved 11 June 2018.
  11. "Newsletter of the Lehigh Valley Section" (PDF). American Chemical Society, Lehigh Valley Section. October 2018. p. 2. Retrieved 5 October 2018.
  12. Heindel, Ned D., ed. (1978). The Chemistry of radiopharmaceuticals. New York: Masson Pub. USA. ISBN 978-0893520199.
  13. Welch, Michael J. (September 24, 2013). Radiopharmaceuticals and Other Compounds Labelled with Short-Lived Radionuclides. Elsevier. p. 77. ISBN 978-1483104164. Retrieved 12 June 2018.
  14. "Ned D. Heindel, Ph.D." UMDNJ-Rutgers University CounterACT Research Center of Excellence. Retrieved 10 October 2017.
  15. "Patents by Inventor Ned D. Heindel". Justia Patents. Retrieved 10 October 2017.
  16. "Ned D. Heindel". Lehigh University. Retrieved 10 October 2017.
  17. Salter, Rosa (August 28, 1995). "Lehigh Professor's Patent Pays Off For Blood Sterilization". The Morning Call. Retrieved 11 June 2018.
  18. Joseph, Laurie B.; Composto, Gabriella M.; Perez, Roberto M.; Kim, Hong-Duck; Casillas, Robert P.; Heindel, Ned D.; Young, Sherri C.; Lacey, Carl J.; Saxena, Jaya; Guillon, Christophe D.; Croutch, Claire R.; Laskin, Jeffrey D.; Heck, Diane E. (September 2018). "Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug". Toxicology Letters. 293: 77–81. doi:10.1016/j.toxlet.2017.11.005. PMC 5938161. PMID 29127031.
  19. Bourke, Jr., Frederic A. "US20140341845A1: Methods and systems for treating cell proliferation related disorders". US Patents. Retrieved 11 June 2018. U.S. Pat. No. 5,216,176 of Heindel discloses a large number of psoralens and coumarins that have some effectiveness as photoactivated inhibitors of epidermal growth factor. Halogens and amines are included among the vast functionalities that could be included in the psoralen/coumarin backbone.
  20. Acton, Q. Ashton (June 21, 2013). Advances in DNA Research and Application (2013 ed.). Atlanta, Georgia: Scholarly Editions. p. 169. ISBN 978-1481682350. Retrieved 11 June 2018.
  21. Heindel, Ned D.; Choudhuri, Mridula; Ressner, Joel; Foster, Natalie (January 1985). "Aminomethyl psoralens. Electrophilic substitution of hydroxymethylphthalimide on linear furocoumarins". Journal of Heterocyclic Chemistry. 22 (1): 73–76. doi:10.1002/jhet.5570220119.
  22. Heindel, Ned D.; Van Dongen, Jacobus M.A.M.; Sachais, Bruce S.; Phillips, John H.; Gallo, Michael A.; Laskin, Jeffrey D. (July 1991). "Syntheses of Psoralen Analogues and Evaluation of Their Inhibition of Epidermal Growth Factor Binding". Journal of Pharmaceutical Sciences. 80 (7): 686–689. doi:10.1002/jps.2600800715. PMID 1941569. Retrieved 11 June 2018.
  23. Laskin, Jeffrey D.; Jan, Yi-Hua; Jetter, Michele M.; Guillon, Christophe D.; Mariano, Thomas M.; Heck, Diane E.; Heindel, Ned D. (May 2018). "Identification of a Pyranocoumarin Photosensitizer that is a Potent Inhibitor of Keratinocyte Growth". Photochemistry and Photobiology. 94 (3): 577–582. doi:10.1111/php.12882. PMID 29315592. S2CID 3634344.
  24. Lally, Robin (December 1, 2016). "Rutgers Receives $19 Million to Develop Drugs to Treat Chemical Weapons Attacks Work aimed at devising drug therapies to counteract deadly chemical poisons". Rutgers Today. Retrieved 10 October 2017.
  25. Lacey, Carl J.; Wohlman, Irene; Guillon, Christophe; Saxena, Jaya; Fianu-Velgus, Cynthia; Aponte, Erik; Young, Sherri C.; Heck, Diane E.; Joseph, Laurie B.; Laskin, Jeffrey D.; Heindel, Ned D. (August 2016). "Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury". Annals of the New York Academy of Sciences. 1378 (1): 174–179. Bibcode:2016NYASA1378..174L. doi:10.1111/nyas.13177. PMC 5063683. PMID 27505078.
  26. Gordon, Marion; Rodrigues, Andrea; Hahn, Rita; Gerecke, Donald; Svoboda, Kathy; Heindel, Ned (June 2013). "Corneal Wound Healing is Facilitated by Hydroxamates that Reduce EMMPRIN Expression". Investigative Ophthalmology & Visual Science. 54: 3910. Retrieved 12 June 2018.
  27. "Board of Directors". Pennsylvania Drug Discovery Institute. Retrieved 10 October 2017.
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  30. "ACS Fellows". Retrieved 10 October 2017.
  31. Achilladelis, Basil; Bowden, Mary Ellen (1989). Structures of Life: To Accompany an Exhibit by the Beckman Center for the History of Chemistry. Philadelphia, Pa.: Beckman Center for the History of Chemistry. p. 37. ISBN 978-0-941901-07-9. Retrieved 10 October 2017.
  32. "The History of CHF". Chemical Heritage: Newsmagazine of the Chemical Heritage Foundation. 18 (1): 16–22. 2000-02-01.
  33. Heindel, Ned (2000). "The story behind the story". Chemical Heritage Magazine. Chemical Heritage Foundation. 18 (3): 45.
  34. Wotiz, John H. (2000). "History of Chemistry: The ACS Centre in Philadelphia". Chemical Heritage. 18 (3): 45–46.
  35. Heindel, Ned D.; Sturchio, Jeffrey L.; Bohning, James J. (2018). "Chapter 14: The Professionalization of American Chemistry: How the German Ph.D. Model Crossed the Atlantic". In Rasmussen, Seth C. (ed.). Igniting the Chemical Ring of Fire. New Jersey: World Scientific. pp. 387–426. doi:10.1142/9781786344557_0014. ISBN 978-1-78634-454-0.
  36. Heindel, Ned D.; Pfau, Michel A. (July 1965). "A profitable partnership: Giacomo Ciamician and Paul Silber". Journal of Chemical Education. 42 (7): 383. Bibcode:1965JChEd..42..383H. doi:10.1021/ed042p383.
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  38. Heindel, Ned D.; Rapp, Robert D. (2011). The Nineteenth-century horse doctor : a Pennsylvania Dutchman's practical guide for treating horses. Seattle, WA: Coffeetown Press. ISBN 9781603811217.
  39. White, Thomas (2013). Witches of Pennsylvania : occult history & lore. Arcadia Publishing. ISBN 978-1626191327.
  40. Bentley, Tiffany (Oct 29, 2011). "Witchcraft in Williams Township, a history of the good and evil". Lehigh Valley Live. Retrieved 11 June 2018.
  41. Merlin, Michelle (October 30, 2016). "Haunted rock legends live on in technology, religion". AP. Retrieved 11 June 2018.
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  43. "On the Shelf: Hexenkopf: History, Healing and Hexerei". Papers Falling from an Attic Window. 2006-08-06. Retrieved 11 June 2018.
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  47. Clark, Kathryn Finegan (2018). "Once upon a time in Durham". Bucks County Herald. Retrieved 16 July 2018.
  48. Kraus, Scott; Palochko, Jacqueline (October 14, 2014). "Proposed 105-mile PennEast pipeline rattles residents". The Morning Call. Retrieved 21 February 2018.
  49. "Land Preservation Board". Williams Township, Northampton County, PA. Retrieved 21 February 2018.
  50. Hurdle, Jon (February 8, 2018). "PennEast pipeline seeks eminent domain, plus U.S. marshals to protect workers". StateImpact. NPR. Retrieved 21 February 2018.
  51. Hurdle, Jon (February 15, 2018). "Pipeline Conflict Heats Up: Landowners Vow to Fight PennEast on Eminent Domain". NJ Spotlight. Retrieved 21 February 2018.
  52. Hurdle, Jon (February 19, 2018). "Landowners brace for eminent domain loss in PennEast pipeline cases". StateImpact. NPR. Retrieved 21 February 2018.
  53. Wright, Emma (February 20, 2018). "Residents fight for their land against PennEast pipeline". 69 News. Retrieved 21 February 2018.
  54. Palochko, Jacqueline (November 9, 2014). "Newsmaker Q&A: Linda Heindel, PennEast Pipeline opponent". The Morning Call. Retrieved 21 February 2018.
  55. "Hillman Faculty Award". University Awards. Lehigh University. Retrieved 10 October 2017.
  56. Berg, Christian (May 17, 2002). "Ben Franklin Technology center honors eight leaders for contribution to economy". The Morning Call.
  57. "Dr. Henry A. Hill Distinguished Lecture". National Organization for the Professional Advancement of Black Chemists and Chemical Engineers. Retrieved 10 October 2017.
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Sources
  • American men & women of science, 1995-96 : a biographical directory of today's leaders in physical, biological and related sciences. 3 (19th ed.). New Providence, New Jersey: R. R. Bowker. 1996. pp. 739–740. ISBN 978-0835234665.
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