Osteoglycin

Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein.[5]

OGN
Identifiers
AliasesOGN, OG, OIF, SLRR3A, osteoglycin
External IDsOMIM: 602383 MGI: 109278 HomoloGene: 8542 GeneCards: OGN
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q22.31Start92,383,268 bp[1]
End92,404,696 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4969

18295

Ensembl

ENSG00000106809

ENSMUSG00000021390

UniProt

P20774

Q62000

RefSeq (mRNA)

NM_033014
NM_014057
NM_024416

NM_008760

RefSeq (protein)

NP_054776
NP_077727
NP_148935
NP_054776.1
NP_148935.1

NP_032786

Location (UCSC)Chr 9: 92.38 – 92.4 MbChr 13: 49.61 – 49.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small keratan sulfate proteoglycan[6] which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.[5]

The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy.[7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000106809 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021390 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: OGN osteoglycin".
  6. Funderburgh JL, Corpuz LM, Roth MR, Funderburgh ML, Tasheva ES, Conrad GW (1997). "Mimecan, the 25-kDa corneal keratan sulfate proteoglycan, is a product of the gene producing osteoglycin". J Biol Chem. 272 (44): 28089–95. doi:10.1074/jbc.272.44.28089. PMID 9346963.CS1 maint: multiple names: authors list (link)
  7. "Big hearts 'have genetic problem'". Health. BBC News. 2008-06-06. Retrieved 2008-06-07.
  8. Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA (May 2008). "Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass". Nat. Genet. 40 (5): 546–52. doi:10.1038/ng.134. PMC 2742198. PMID 18443592.

Further reading

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