Keratocan

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan, is a protein that in humans is encoded by the KERA gene.[5][6][7]

KERA
Identifiers
AliasesKERA, CNA2, KTN, SLRR2B, keratocan
External IDsOMIM: 603288 MGI: 1202398 HomoloGene: 5106 GeneCards: KERA
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q21.33Start91,050,491 bp[1]
End91,057,983 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11081

16545

Ensembl

ENSG00000139330

ENSMUSG00000019932

UniProt

O60938

O35367

RefSeq (mRNA)

NM_007035

NM_008438

RefSeq (protein)

NP_008966

NP_032464

Location (UCSC)Chr 12: 91.05 – 91.06 MbChr 10: 97.61 – 97.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratan sulfate proteoglycans (KSPGs) are members of the small leucine-rich proteoglycan (SLRP) family. KSPGs, particularly keratocan, lumican and mimecan, are important to the transparency of the cornea.[7]

Mutations of the gene cause cornea plana 2.

References

  1. GRCh38: Ensembl release 89: ENSG00000139330 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019932 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tasheva ES, Funderburgh JL, Funderburgh ML, Corpuz LM, Conrad GW (Jan 2000). "Structure and sequence of the gene encoding human keratocan". DNA Seq. 10 (1): 67–74. doi:10.3109/10425179909033939. PMID 10565548.
  6. Pellegata NS, Dieguez-Lucena JL, Joensuu T, Lau S, Montgomery KT, Krahe R, Kivela T, Kucherlapati R, Forsius H, de la Chapelle A (Jun 2000). "Mutations in KERA, encoding keratocan, cause cornea plana". Nat Genet. 25 (1): 91–5. doi:10.1038/75664. PMID 10802664. S2CID 8837115.
  7. "Entrez Gene: KERA keratocan".

Further reading


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