Rise of the Teenage Mutant Ninja Turtles

• Raph (voiced by Omar Benson Miller[5]) – A 15-year-old snapping turtle and initial self-proclaimed leader of the group prior to the second season finale, Raph formerly wields two tonfa in battle that can amplify his own strength with red energy and he had been given new sais in the Season 2 finale with the ability to make clones of himself.[6] In "Mascot Melee", it is revealed that Raph is allergic to peanuts and has a weakness for teddy bears. He has a habit of speaking in the third person in battle. Raph has numerous catchphrases: "Jumpin' Jackflash" when surprised and "Hot Soup" as a battle cry.
• Leo (voiced by Ben Schwartz[5]) – A 14-year-old red-eared slider who is known to be called the "trickster", and thinks that his one liners will "fire up the team"; but has actual encouraging charisma as shown in "Origami Tsunami". Leo wields an ōdachi sword in battle that can open portals, but he had been given new katanas in the Season 2 finale that allows him to teleports himself or others. He enjoys skateboarding and keeps plants in his room.[7] The episode "Minotaur Maze" reveals that Leo has an insecure side. In "The Gumbus", it is shown he feels a need to be right. By the end of the four part "Finale" episodes, Splinter makes Leo the new leader of the group.
• Mikey (voiced by Brandon Mychal Smith[5]) – A 13-year-old ornate box turtle who is the "youngest jokester, prankster brother." He is an affectionate and sensitive artist, and is also called the "wild card". Mikey wields a kusari-fundo in battle that can become a fire spirit, but he had been given new set of nunchaku in the Season 2 finale with the to extend to great length and controls will.[8] In "Donnie's Gifts" and "The Longest Fight", it is revealed that Mikey also has a passion for cooking especially for pizza. He is implied to have a fast metabolism, being miserable in his hunger as seen in "Minotaur Maze" and comparatively to the point of extreme anger as seen in "Pizza Pit".
• Donnie (voiced by Josh Brener[5]) – A 14-year-old spiny softshell turtle. He is the "genius of the team" and relishes praise from others. He has a sidekick drone named S.H.E.L.L.D.O.N. along with many battle shells that he makes in order to help him in battle because of his species. He rejects claiming a magical weapon like his brothers, and instead wields a high-tech version of his traditional bō staff in battle that can transform into a multitude of weapons like drills or a rocket powered hammer. This was destroyed near the end of Season 2, and was replaced with a mystic bō staff with magic energy versions of his gadgets. The new mystic staff could also link up with his technological attachments. [6] In "Mascot Melee", it was revealed Donnie has a crush on a comic book heroine called Atomic Lass. In "Stuck on You", Donnie reveals his computer password is "Bootyyyshaker9000" due to his love of dancing.

• April O'Neil (voiced by Kat Graham[5]) – A human friend of the Ninja Turtles, she has already known them for 5 years prior to when the show started and is like their sister.[9] April is a fun-loving thrill seeking girl with glasses who is constantly looking for a job to support herself which constantly goes wrong. "Hypno: Part Deux!" shows that despite her bravado, she has a hard time making friends at school and is nervous about high school gatherings. When fighting, she also wields a baseball bat.[10] In "Warren & Hypno, Sitting in a Tree", it is revealed that April knows who Warren Stone is as she was part of a fan club dedicated to him called the Stoneheads, and she is 16 years old. In "Donnie vs. Witch Town", April's bat gets enchanted during her visit to the Hidden City's Witch Town district.

• Mayhem / Agent 64 – An unspecified cat/dog-like creature with short-range teleportation abilities that becomes April's pet.[11] It is an agent that worked for the Council of Heads against Baron Draxum and was sent to monitor him.

• Hamato Yoshi / Lou Jitsu / Splinter (voiced by Eric Bauza[5]) – Splinter is a mutant gray rat who is the Ninja Turtles' sensei and father. He is fond of watching the projects of Lou Jitsu, milk, and cake. His training of the Turtles manifests in copying and watching Lou Jitsu tapes, which is revealed to be more effective than the brothers expected. In "The Evil League of Mutants" and "Shadow of Evil", Splinter is revealed to be Hamato Yoshi as he neglected to carry out out the Hamato Clan's mission in preventing Shredder's return by working in Hollywood under the stage-name of "Lou Jitsu". He acquired a large fanbase during his career including Baron Draxum, who used his genetic sample to create the Turtles, and some members of the Foot Clan. His use of unconventional weaponry is inspired by Jackie Chan.[12] The flashback sequences of "Many Unhappy Returns" and "Goyles, Goyles, Goyles" reveal how Yoshi was abducted by Big Mama to fight in the Battle Nexus and his later mutation, from being constantly bitten by a rat, while Draxum used his DNA to create the Turtles.

• Baron Draxum (voiced by John Cena in season 1,[13][14] Roger Craig Smith in season 2) – A maroon-skinned Yōkai warrior and alchemist from the Hidden City with maroon hair and faun-like legs, who has the power to augment his own body by crushing purple pods in his hands, and can manipulate giant purple tentacle-like vines to grab objects, enemies, or as a means of transportation. As the self-proclaimed protector of all mutantkind, Baron Draxum seeks to mutate humanity to avert a prophecy predicting the destruction of the Yōkai.[15] An incident amidst an earlier attempt to turn humanity into Yōkai led to the creation of the Teenage Mutant Ninja Turtles while causing Hamato Yoshi's transition into Splinter, attempting to win the former to his side before joining forces with the Foot Clan to reassemble the Kuroi Yōroi and revive Shredder. In "How to Make Enemies and Bend People to Your Will", Draxum exploits a loophole in the Foot's rules to becomes its leader through tactics that enable him to gain a shard of the Kuroi Yōroi that the Foot Lieutenant and Foot Brute failed to acquire. In the episode "End Game", Draxum equips the restored Kuroi Yōroi armor with the intention of destroying humanity once and for all. The Foot Lieutenant and Foot Brute address him as Shredder, but he rejects the title, confused with the name "Shredder". Due to a Jupiter Jim action figure being wedged in a hole in the back of the helmet, the Turtles managed to attack that part and cause the armor to fall off of Draxum, though the armor is revived after siphoning some of Draxum's life force, degrading his body to nearly a corpse and weakening his powers considerably. After the Foot Recruit emerged from the portal, Draxum used his weakened abilities to escape through it. In "Repairin' the Baron", Mikey takes in a weakened Draxum and teaches him to tolerate humans with Raph's help. After saving a mother and daughter from the ferris wheel during Garm and Freki's attempt to capture him at Albeartoland while losing his mask in the process, and slowly starting to regain his lost power, he starts to tolerate humans, after which, Raph and Mikey get him a job working at the cafeteria at April's school. In the four part "Finale" episodes, Draxum realized that Shredder was the threat to the Yōkai mentioned in the prophecy, not humanity.

• Todd Capybara (voiced by Thurop Van Orman) – A friendly mutant capybara and selfless charitable proprietor of Cuddles Cakes Puppy Rescue on Long Island. In exchange for Todd giving up his RV, Michelangelo and Donatello build a new type of residence for Todd and his rescue puppies. In "Portal Jacked", Todd has a picture in Run of the Mill Pizza that lists him as a "best customer".

• Señor Hueso (voiced by Eric Bauza) - A skeleton who uses his own left arm for a cane. He is the doorman and manager of the pizza parlor called Run of the Mill Pizza in New York's mystical Undercity. In "Portal Jacked", Senor Hueso has the brother named Capitán Piel. Señor Hueso's name is Spanish for "Mr. Bone".

• Stanley / Bullhop (voiced by Dave Foley) - A Canadian immigrant and bellhop who worked at The Grand Nexus Hotel that was actually a front for Big Mama's Battle Nexus. When the Oozesquitoes swarmed in the hotel, the Turtles tried to keep Stanley from getting stung only to fail. As a result of his consumption of beef jerky as noted by Big Mama, Stanley is turned into a mutant bull and flees the hotel. After the Turtles try to make up for their mistake, he becomes their friend and develops advanced dancing skills. This character is a homage to Jerry Lewis' role in the movie The Bellboy.

• DIGG - A trio of girl rock musicians longing for their breakthrough. Turned into a mutant burrowing animal by the Oozequitoes during one of their gigs, they attempt a misguided scheme to win themselves an attentive debut audience by targeting the different pizzerias. With the Turtles' aid, they finally become an attraction as pizzeria musicians while also reuniting a family of pizza makers.
  • Prairie Dog (voiced by E. G. Daily) - A mutant prairie dog who is the group's lead singer and guitarist.
  • Ground Hog (voiced by Betsy Sodaro) - A mutant groundhog who is the group's dig-obsessed drummer. She has a tendency to say "dig" when she is burrowing.
  • Honey Badger (voiced by E. G. Daily) - A mutant honey badger who is the group's secondary guitarist. She is the strongest of the group.

• Sunita (voiced by Kody Kavitha) - A slime Yōkai that can explode and reassemble at will. She can assume a human form thanks to a special amulet. At the time of meeting April and the Turtles, Sunita was wearing metal boots that turned out to be a part of the Kuroi Yoroi leading her to be targeted by the Foot.

• Frankenfoot (voiced by Rob Paulsen) - A patchwork Origami Ninja put together by Raph as a sparring partner. He becomes a permanent member of the team, even earning a Turtle insignia courtesy of Mikey.

• S.H.E.L.L.D.O.N. (voiced by Greg Cipes) - An A.I. invention that is devoted to its creator Donnie causing a disgruntled Raph, Leo, and Mikey to reprogram and thus inadvertently turning it against their brother. Donnie was able to fix it.

• Piebald (voiced by Chelsea Peretti) - A goldfish that is owned by Splinter and was accidentally flushed down the toilet by Leo months ago. After traversing through the sewers and nearly being eaten by Trash Wizard, Piebald swallowed an Oozesquito and mutated into her current form with camouflage abilities. She secretly returned to the lair and masterminds a scheme with Splinter to teach the Turtles a lesson actions by picking them, Splinter, and Frankenfoot off one by one.

• Gentry (voiced by Evanna Lynch) - A young Yōkai witch from the Hidden City's Witch Town district who befriends April and (though much less) Donatello.

• Hamato Karai (voiced by Gwendoline Yeo) - The founder of the Hamato Clan and the daughter of Oroku Saki. She and the Hamato Clan defeated Shredder at the cost of Karai being imprisoned in the Twilight Realm.

• Cassandra "Casey" Jones (voiced by Zelda Williams) - First appearing under the alias of the Foot Recruit, Cassandra Jones is female member of the Foot Clan with a hyper-aggressive personality who is a genderbent version of Casey Jones, and debuted in "Hot Soup: The Game". In "How to Make Enemies and Bend People to Your Will", Cassandra assists Baron Draxum in getting a Kuroi Yōroi fragment from a statue in the botanical gardens so that she can be able to move up. In "Battle Nexus: New York", Cassandra was placed in a cruise by Shredder so that Big Mama can make New York into the Battle Nexus. She was the one who found that Big Mama was controlling the Shredder using a control device on him and it's associated magic ring. When she claims the magic ring, Cassandra controls the Shredder into destroying the Grand Nexus Hotel as she shouts the Foot Clan's name. When the Shredder regained his power of speech, he promoted Cassandra to the rank of Foot General and had her perform the ritual to drain Splinter's essence. Cassandra later defected to the Turtles' side and helped to defeat the Shredder while revealing her true name to them.

• Hamato Atsuko (voiced by Keiko Agena) - Hamato Yoshi's late mother who died in her duty to her family's destiny to contain the Shredder while Yoshi was still a child.

• Foot Clan – A ninja clan seeking to resurrect the Shredder and take over New York City. They can make origami ninjas out of paper and have the power of teleportation through hidden gateways. In "Shadow of Evil", it is revealed that the Foot uses a shoe store called the Foot Shack as a front for their activities. Most of its members have been fans of the Lou Jitsu films. In "How to Make Enemies and Bend People to Your Will", Baron Draxum took command over the Foot after exploiting a loophole in the clan's rulings of leadership. However, in "End Game" and "Many Unhappy Returns", it is revealed that the Foot were just manipulating Draxum into donning the Kuroi Yōroi so it could drain his life force to reassemble and resurrect the Shredder.
  • Oroku Saki / Shredder (voiced by Hoon Lee) - The original leader of the Foot Clan. 500 years ago, Oroku Saki was possessed by the demonic Kuroi Yōroi armor that swallowed his soul after having to make a deal with a horrible Oni, which was revealed in the final episode to have been Krang, to forge this nigh-unstoppable armor. Shredder terrorized Japan until he was defeated by the Hamato Clan with his armor being broken into pieces and scattered across the world to prevent his return. The Foot and Baron Draxum began seeking out the fragments of the Kuroi Yōroi to reassemble it and resurrect the Shredder, the latter being tricked into wearing the armor so his life force can be siphoned. Shredder reconstitutes himself after the Turtles broke the armor off of Draxum, through only as a feral beast due to something that went wrong with his resurrection. Big Mama provides a bauble for the Turtles and Splinter to trap Shredder in another dimension, though she makes a secret last-minute alteration to this plan. This was revealed to have involved placing a control device on the Shredder and using the associated magic ring to control Shredder into being "Shadow Fiend" and abducting Meat Sweats, the Foot Recruit, Hypno-Potamus, Ghostbear, and Carl Sando for her Battle Nexus tournament in New York. When the Foot Recruit claims the magic ring, she controls the Shredder into destroying the Grand Nexus Hotel as she shouts the Foot Clan's name. When the Turtles, April, and Splinter went into the Twilight Realm to get the weapon needed to defeat Shredder, the side effect caused Shredder to regain his intelligence. When he captured Splinter and Baron Draxum, Shredder made the Foot Recruit his general perform a ritual to drain Splinter's essence. With help from the Hamato Clan, the Turtles defeated Shredder by vanquishing the Kuroi Yōroi for good and brought back Oroku Saki to the Hamato Clan.
  • Foot Lieutenant (voiced by Rob Paulsen) – A leading officer of the Foot Clan.
  • Foot Brute (voiced by Maurice LaMarche) – A buff member of the Foot Clan who works alongside Foot Lieutenant.
  • Jocelyn (voiced by Cree Summer) - A Foot Initiate who gains the mark of the Foot in "How to Make Enemies and Bend People to Your Will". Foot Recruit claimed to Baron Draxum that she got the mark because her parents are "big donors".
  • Foot Soldiers (Various Voices) - An army of ninjas that are associated with the Foot Clan.
  • Origami Ninjas – Ninjas made out of paper that are created by Foot Lieutenant and Foot Brute.

• Huginn and Muninn (voiced by Timothy Simons and Sam Richardson[16]) – Two small gargoyles with retractable wings that were often seen sitting on Baron Draxum's shoulders. Huginn has a frog-like body and a cat-like head and tail while Muninn has a frog-like body and a tapir-like head. Their name and presence as Draxum's constant companions are a play on Odin's ravens Huginn and Muninn. In the episode "Goyles, Goyles, Goyles", Huginn and Muninn are shown to be looking for new employment after Draxum went into hiding due to his life force being drained by the Kuroi Yōroi. It is then shown in a flashback that Huginn and Muninn were constantly mistreated by their fellow gargoyles before being hired by Draxum. It is also revealed that it was actually their fault Hamato Yoshi escaped and destroyed Draxum's laboratory, killing all of Draxum's other test subjects. The duo are not seen again for the rest of the series.

• Garm and Freki (voiced by Fred Tatasciore) – Two guardsmen warriors that worked for Baron Draxum who are experts at armed combat. They can also ride giant demon-like dogs. In "Repairin' the Baron", Garm and Freki are offered forgiveness from the Council of Heads if they bring Draxum to the Hidden City to stand trial for his crimes. They are later mentioned by Draxum to Raph and Mikey to be bounty hunters that work for whoever has the most money. Their names are a play on the wolf monster Garmr and Odin's wolf Freki.

• Oozesquitos – A swarm of mutant mosquitoes that are often used by Baron Draxum.[17] They store mutagen in their abdomens in order to inject anyone they bite which turn them into mutants. The Oozesquitoes are first seen when Draxum tests the mutagen on a delivery guy named Stewart. In the Turtles first encounter with Draxum, they accidentally unleash the Oozesquitos into New York City. The episode "Bug Buster" reveals that Big Mama uses the Oozesquitos so that they can fight for her entertainment in the Battle Nexus much to the annoyance of Draxum. In addition, he also had a hand in the Ninja Turtles' origins. As Draxum called them his "bugs", Huginn and Muninn stated that the Turtles called them Oozesquitoes, which is catchy to them.

• Mutant Silverfish – A bunch of mutant silverfish. If they are attacked, the Mutant Silverfish will split into smaller silverfish that would later aggregate back to its original state.

• Rupert Swaggart / Meat Sweats (voiced by Johnny Rotten[18]) – A former celebrity chef who was turned into a mutant domestic pig upon being stung by an Oozesquito while hitting a failing contestant with a slab of pig meat during his TV show "Kondescending Kitchen". He wears gray gloves to conceal his tendril arms, which he uses to temporary absorb the abilities of any other mutants and wields a meat tenderizer in battle. Meat Sweats habitually makes any mutant he catches into his "meals" to strengthen the "flavor".[19]

• Albearto (voiced by Tom Kenny[18]) – An animatronic brown bear used at children's birthday parties in Albearto's Pizzeria.[20] After a small child short-circuited him, April had Donatello upgrade him where a stage mishap caused Albearto to get electrocuted and come to life. In "Al Be Back", Albearto returns where his head was salvaged by Baxter Stockboy in exchange for the cheat codes for the dance game. While on a car, he places his head on a new Albearto body in front of the birthday kids, gets the manager's hand print for the security scanner, and animates his bear "brothers" from failed franchises to attack Albearto Land where Albearto also animated the Albearto animatronics there. The Ninja Turtles put on a concert that Albearto and his animatronic "brothers" attend which causes most of them to destroy themselves after the Ninja Turtles' singing drives them mad. Albearto is the only one to escape, but his final fate is left unclear.
  • Al-Beardo the Pirate (voiced by Tom Kenny) - An animatronic bear pirate with a hook for a right hand, an eyepatch over his right eye, and a left peg leg who is the mascot of a failed Albearto's British- and pirate-themed franchise called "Al-Beardo's Squid and Chips".
  • Bayou 'Bearto (voiced by Tom Kenny) - An animatronic bear hillbilly who is the mascot of a failed unnamed, Southern state-themed Albearto franchise.
  • Chef Albéar (voiced by Tom Kenny) - An animatronic bear who is the mascot of a failed Albearto's Pizzeria franchise called "La Petite Albear".
  • Otto von Bearto (voiced by Tom Kenny) - An animatronic bear who is the mascot of a failed Albearto's Pizzeria franchise called "Otto von Bearto's Best Wurst House".

• Warren Stone (voiced by John Michael Higgins[18]) – A semi-successful and narcissistic news anchor who mutated into a small mutant earthworm with an earthworm tail instead of legs after being stung by an Oozesquito.[20] If cut in half, Warren can regenerate. Since his mutation, he self-declared himself the greatest foe of the Teenage Mutant Ninja Turtles always ignore him. Warren Stone later gains a gauntlet that can shoot beams which he named Charlotte. This was later found to be one piece of the Kuroi Yoroi that was needed to revive Shredder. In "Warren & Hypno, Sitting in a Tree", Warren has become a roommate of Hypno-Potamus and also loses the gauntlet to Baron Draxum so that the Foot Clan can use it in their plot to revive Shredder, though April does remember who Warren is since she was part of the Stoneheads.

• Mezmer-Ron / Hypno-Potamus (voiced by Rhys Darby[18]) – A successful stage magician and hypnotist who mutated into a hippopotamus after he was stung by an Oozesquito that merged him with his pet hippopotamus Doug.[20] Driven by envy, Hypno-Potamus strives to outachieve any magician with an even greater "trick" than they can produce, and find a way to bring Doug back to life, leading to his clashes with the Teenage Mutant Ninja Turtles. In "Warren & Hypno, Sitting in a Tree", Hypno-Potatmus has become a roommate of Warren Stone.

• Repo Mantis (voiced by Fred Tatasciore[18]) – The vicious, treacherous, and greedy owner of a salvage yard called Repo Mantis Salvage who was mutated into a purple mutant mantis after being stung by an Oozesquito. His mutation has not affected his salvaging business.
  • Mrs. Nubbins - Repo Mantis' pet cat who was stung by an Oozesquito and mutated into a cat/mantis hybrid due to having been in contact with her owner. Due to the mantis' nature, Mrs. Nubbins would try to eat Repo Mantis causing him to keep her locked up.

• Ghostbear (voiced by Jorge Gutierrez[18]) – A human masked wrestling champion in a white bear cape who cheats. Raphael was a fan of him until he learned the truth about his fighting techniques. In "Snow Day" while trying to get revenge on the Turtles for ruining his pro wrestling career, Ghostbear is stung by a defrosted Oozesquito and mutated into a mutant polar bear. This new form gives him the ability to become intangible.

• Mutant Cockroach Gang - An unnamed group of mutant cockroaches that posed as mascots.
  • Atomic Lass (voiced by Grey Griffin) - An unnamed mutant cockroach dressed as Atomic Lass.
  • Joey the Junkyard Dog (voiced by John DiMaggio) - An unnamed mutant cockroach dressed as Joey the Junkyard Dog.
  • Robot Vampire (voiced by Grey Griffin) - An unnamed mutant cockroach dressed as Robot Vampire.
  • Sergeant Woodpecker (voiced by Eric Bauza) - An unnamed mutant cockroach dressed as Sergeant Woodpecker.

• Baxter Stockboy (voiced by Ramone Hamilton) - An unpaid stockboy and self-proclaimed "internet celebrity". Both vengeful and avaricious, he strives to either profit from his live-streamed schemes or take revenge on anyone (particularly the Turtles) who hinders him in doing so.

• Mrs. Cuddles (voiced by Eliza Schneider) - A plush rabbit character from the TV series of the same name who comes to life to feeds on fear of her to become bigger and stronger. If someone laughs at her, Mrs. Cuddles loses her size and strength.

• Big Mama (voiced by Lena Headey[18]) – A cunning Jorōgumo who can change between her purple-skinned human form and her humanoid spider form and has a habit of using improper upper-class words when she speaks. She is the owner of an extradimensional gladiator arena called the Battle Nexus which is hidden in the secret sub-level of The Grand Nexus Hotel that is owned by her human form. Big Mama uses the Oozesquitos in her possession to mutate anyone into mutants so that they can fight for her entertainment in the Battle Nexus. Her plot has brought her into conflict with Baron Draxum who felt that Big Mama was misusing the Oozesquitos. Hinted in "The Ancient Art of Ninja Hide and Seek", the episode "Many Unhappy Returns" reveals that Big Mama was the ex-girlfriend of Hamato Yoshi and the indirect cause of his mutation when she abducted him to fight in the Battle Nexus. In "Battle Nexus: New York", Big Mama transported the population of New York to a cruise inside a mystical sphere so that she can have the Turtles and their mutant enemies fight her Battle Nexus Champions. Once the Battle Nexus Champions are defeated, the Turtles go to the Grand Nexus Hotel to confront Big Mama and her latest champion Shadow Fiend. The Foot Recruit found that Shadow Fiend is actually Shredder who is being controlled by a control device on him by Big Mama using the device's associated magic ring. Once the Foot Recruit claimed the magic ring and gains control of the Shredder, she tells a cowering Big Mama that she is about to lose everything as she advises her to start running. The Grand Nexus Hotel is then destroyed by the Shredder. The Turtles later found Big Mama in a cave recuperating from her injuries as she directs them to the Crying Titan where the Empyrean that Shredder needs is located.
  • Gus (voiced by Fred Tatasciore) - A mutant bulldog that is loyal to Big Mama who can grow spikes on his body. Gus is prone to partaking in a game of fetch.
  • Fox Bellhop (voiced by Eric Bauza) - An unnamed mutant red fox that works as a bellhop at Big Mama's Battle Nexus.
  • Octopus Elevator Operator (voiced by Nolan North) - An unnamed mutant octopus that works as an elevator operator at the Grand Nexus Hotel. In "Turtle-dega Nights: The Ballad of Rat Man", the Octopus Elevator Operator served as the announcer of the mutant demolition derby and was miscredited as the "Penguin Bellhop."
  • Otter Bellhop (voiced by Nolan North) - An unnamed mutant North American river otter that works as a bellhop at Big Mama's Battle Nexus.
  • Owl Bellhop (voiced by Fred Tatasciore) - An unnamed mutant barn owl that works as a bellhop at Big Mama's Battle Nexus.
  • Battle Nexus Champions - A group of powerful fighters from the Battle Nexus.
    • Troll - A troll with a lion-like head who wields a club. He fights Raph and Ghostbear on a bridge where the two of them do the Hibernator move to fool it and Big Mama.
    • Sprite (voiced by Zelda Williams) - A sprite who never laughs. She fights Leo and Carl Sando while possessing the Statue of Liberty. Leo and Carl were able to defeat it by doing comical moves that she found funny.
    • Amphisbaena - A two-headed serpent with an insatiable appetite. It fights Mikey and Meat Sweats where the two of them had to satisfy its appetites. Both of them worked together to do that job.
    • Cortex (voiced by Eugene Byrd) - A Cthulhu-like creature with extremely high intelligence. He fights Donnie and Hypno-Potamus in a chess match. Both of them managed to come up with a strategy to defeat Cortex.

• Purple Dragons - A trio of snobby, criminal tech club students at April's high school. They are skilled at computer hacking, high-tech theft, and other technology-based abilities.
  • Kendra (voiced by Tania Gunadi) - The leader of the Purple Dragons. She has known April since kindergarten. In "Breaking Purple", it is revealed that Kendra's dad married Jase's mom, making them step-siblings.
  • Jase (voiced by Eugene Byrd) - Member of the Purple Dragons. He has a fear of cats and dogs. In "Breaking Purple", it is revealed that Jase's mom is married to Kendra's dad making them step-siblings.
  • Jeremy (voiced by Kyle Massey) - An African-American member of the Purple Dragons. He refers to Kendra as "chief",

• Sando Brothers - Two acrobat brothers in a circus who were turned into mutant crabs by Oozesquitos. They can attack by launching their left claws at their opponents.
  • Ben Sando (voiced by Paul Scheer) - The first half of the Sando Brothers who has no hair.
  • Carl Sando (voiced by Jason Mantzoukas) - The second half of the Sando Brothers who has hair.

• Capitán Piel (voiced by Christian Lanz) - A living skin who is the brother of Señor Hueso and the pirate captain of the S.S. Alexis. His name is Spanish for "Captain Skin".
  • Kraken Pirate (voiced by Eric Bauza) - A humanoid kraken who is a member of Capitán Piel's pirate crew.
  • Mermaid Pirate (voiced by Rob Paulsen) - A mermaid who is a member of Capitán Piel's pirate crew.
  • Sea Serpent Pirate (voiced by Maurice LaMarche) - A humanoid sea serpent who is a member of Capitán Piel's pirate crew.

• Makers of Brutality - The Makers of Brutality are a gang of ogres.
  • Boss Beverly (voiced by Gillian Vigman) - A one-eyed ogre who is the leader of the Makers of Brutality.
  • Ogre Henchmen (voiced by Gillian Vigman) - The unnamed henchmen of Boss Beverly.

• Masters of Barbarianism - The Masters of Barbarianism is a gang of reptilian creatures.
  • Boss Bruce (voiced by Vic Chao) - A humanoid Japanese dragon with an eyepatch over his left eye who is the leader of the Masters of Barbarianism.
  • Snake Henchmen (voiced by Eric Bauza and Vic Chao) - The unnamed humanoid snake henchmen of Boss Bruce who can attack like snakes.

• Dr. Alex Noe (voiced by Tony Hale) - A dentist obsessed with collectiong teeth from extremely rare or unusual creatures, including Raph's snaggleteeth.

• Sloppy Joseph - When an Oozesquito in Baron Draxum's possession gets loose in the kitchen, he and April trap it in a pot. This causes the Oozesquito to mutate the mystery meat concoction that Draxum made inside the pot to create a mutant that is named Sloppy Joseph (a pun on the term "sloppy joe"). Sloppy Joseph can get bigger from every food that it consumes.

• Scor-Pion (voiced by John Kassir) - A zookeeper who was stung by an Oozesquito and mutated into a mutant scorpion after he was pushed into the scorpion habitat by his co-workers. Marcus Moncrief once mistook him for an alien.

• Mud Dogs - A group of criminals operating in the Hidden City who mistook Raph as Heinous Green.
  • Dastardly Danny (voiced by Rob Paulsen) - The leader of the Mud Dogs.
  • Loathsome Leonard (voiced by Seth Green) - A member of the Mud Dogs.
  • Malicious Mickey (voiced by Greg Cipes) - A member of the Mud Dogs.

• Heinous Green - A size-shifting green Yōkai who is one of the most wanted criminals in Hidden City. The Hidden City Police mistook Raph for this villain.

• Kristoff van Bradford (voiced by Peter Stormare) - A martial arts action star and Lou Jitsu's rival who took over most of Lou Jitsu's dojos and teaches his students to do dishonest martial arts moves. He is loosely based on the character Chris Bradford from the 2012 series and John Kreese from The Karate Kid.
  • Komodo Dojo Students (four of them voiced by Jill Talley) - Five students at the Komodo Dojo who are loyal to Kristoff.
    • Frank (voiced by Eric Bauza) - One of Kristoff Van Bradford's students.
  • Komodo Dragon Yōkai - An unnamed Komodo dragon Yōkai which can infuse anyone it bites with mutagen, endowing them with superhuman strength. It is used by Kristoff van Bradford in his attempts to take over the Lou Jitsu dojos. Loosely based on the character King Komodo from the Image Comic series.

• Stewart (voiced by Fred Tatasciore) - A food delivery man who accidentally fell into the Hidden City after mistaking a portal opened by Garm and Freki for a shortcut. He was then captured by Baron Draxum, who then used an Oozesquito to turn him into a mutant whitefish after which he runs off in a panic; his mutation refers to the fact his employers were committing food fraud, specifically the use of imitation crab in their crab cakes, which he claimed was real crab. In "Bug Buster", Stewart was seen fighting in the Battle Nexus where he engaged an octopus elevator operator in a slap fight.

• Clem (voiced by Eric Bauza) - The owner of a candy shop who can shift between a pink-skinned human form and a magenta mutant goat form. His shop is a front where he sells magical items. To access the magical items, the password one has to say is "wink", although it is easy to get the password as Clem often accidentally tells it to the customers.

• Trash Wizard (voiced by Eric Bauza) - A man who dresses as a wizard and likes to dramatically place himself in the Turtles' path (especially during high-speed pursuits) as he yells "You shall not pass!"

• Hidden City Police Officers (voiced by Eric Edelstein and Audrey Wasilewski) - The unnamed members of the Hidden City Police Department. The male one resembles a humanoid winged lion and the female one is an unspecified creature.

• Exploding Frankie (voiced by Eric Bauza) - A slime Yōkai that can explode and reassemble at will. He is the father of Sunita and works as a birthday entertainer at Run of the Mill Pizza.

• Harold / Stinkbomb (voiced by James Adomian) - The leader of the property caretakers of a botanical gardens who led his fellow caretakers in fighting the Foot Clan when they trespassed. After he saw that the corpse flower named Jewell was sliced, he rushed in and got it out in order to save it. To further his plans to take over the Foot and gain the Kuroi Yōroi, Baron Draxum deployed his Oozesquitoes who mutated Harold into a mutant corpse flower that started attacking both sides in order to get them off the grass.

• Bat Librarian (voiced by Gillian Vigman) - A four-armed bat-like creature who works at the Undercity's library.
  • Hush-Bats - A swarm of bats who work for the Bat Librarians. They will carry off anyone who makes a sound and place them in the kiddie room.

• Marcus Moncrief (voiced by Phil LaMarr) - An actor who portrays Jupiter Jim, the titular character of a long-running fictional science fiction adventure franchise. Secretly insane, he believes himself to be Jupiter Jim to the point of building fully functional versions of his Jupiter Jim movie weapons, paralyzing his own fans, and dressing them up as trophies for his private Jupiter Jim museum.
  • Red Fox (voiced by Lauren Lapkus) - A red panda-type Yōkai with a prehensile tail who was Marcus Moncrief's co-star in the Jupiter Jim movies. She left after not being respected by Marcus. Leo, Mikey, and Donnie once encountered her at the theater that was doing a Jupiter Jim musical where she worked to deny any knowledge that she is a Yōkai. Red Fox later saved Marcus and Raph from Scor-Pion's trap. Afterwards, Marcus thanked Red Fox for saving him which Red Fox finally got from him.

• Council of Heads (voiced by Susan Blu, Peter Cullen, and Frank Welker) - A trio of stone heads that run the Yōkai community. They are against Baron Draxum's plot to mutate humanity, finding his experiments as an offense against their very nature, and sent Agent 64/Mayhem to spy on him. In the episode "Reparin' the Baron", the Councilors are furious at Draxum for his crimes against both humanity and the Yōkai. However, they promise to forgive Garm and Freki for their assistance in his crimes, but only if they bring the Baron to the Hidden City to stand trial.

• Loose Lips Malinowski (voiced by Russ Carney) - A fence constantly on the lookout for easy money. As his nickname signifies, he is prone to unconsciously spilling his beans to anyone asking him a direct question about his dealings.

• Mayor Mira (voiced by Kathy Najimy) - A witch who is the mayor of the Hidden City's Witch Town district.

• Hamato Sho (voice by Matthew Yang King) - Hamato Yoshi's maternal grandfather against whom Yoshi became embittered for trying to push onto him the tradition of the Hamato Clan to prevent the Shredder's return, a duty which took his mother away from him during his childhood.

The entire second season aired on Nicktoons.

IDW published a comic book based on the series, beginning in July 2018.[78] The comics concluded with an introductionary issue (#0), a five-issue main story and a Halloween Comicfest special. After a period of inactivity, it was continued with a three-issue story arc titled "Sound Off!" from July to September 2019.

On February 16, 2018, the first toys based on the series were presented during the New York City Toy Fair.[79] The first Rise of the Teenage Mutant Ninja Turtles toys are expected to be released on October 1, 2018, but are starting to leak out on store shelves on September 20, 2018.[80]

In August 2018, the American fast food chain Sonic Drive-In released a set of kids meal toys based on the series, which were available in their Wacky Pack meals.

During the months leading up to the series' launch, Viacom and Nintendo collaborated to market Rise of the Teenage Mutant Ninja Turtles via a special limited-time online multiplayer event for the 2017 video game Splatoon 2, in which Inklings can participate in a Splatfest tournament, battling over which of the four brothers is the best. Donnie won overall, beating Mikey in the first round, and Raph (who had in turn beat Leo) in the finals.[81][82]