SLC22A7

Solute carrier family 22 member 7 is a protein that in humans is encoded by the gene SLC22A7.[5][6][7]

SLC22A7
Identifiers
AliasesSLC22A7, NLT, OAT2, solute carrier family 22 member 7, hOAT11
External IDsOMIM: 604995 MGI: 1859559 HomoloGene: 21328 GeneCards: SLC22A7
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.1Start43,295,694 bp[1]
End43,305,538 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10864

108114

Ensembl

ENSG00000137204

ENSMUSG00000067144

UniProt

Q9Y694
Q5T051

Q91WU2

RefSeq (mRNA)

NM_006672
NM_153320

NM_144856

RefSeq (protein)

NP_006663
NP_696961

NP_659105

Location (UCSC)Chr 6: 43.3 – 43.31 MbChr 17: 46.43 – 46.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000137204 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000067144 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (Jul 1998). "Identification of multispecific organic anion transporter 2 expressed predominantly in the liver". FEBS Lett. 429 (2): 179–82. doi:10.1016/S0014-5793(98)00585-7. PMID 9650585. S2CID 30015233.
  6. Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM (Jun 2000). "Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids". Cytogenet Cell Genet. 88 (1–2): 76–7. doi:10.1159/000015489. PMID 10773670. S2CID 8702529.
  7. "Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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