TPSD1

TPSD1
Identifiers
Aliases	TPSD1, MCP7-LIKE, MCP7L1, MMCP-7L, tryptase delta 1
External IDs	OMIM: 609272 HomoloGene: 130655 GeneCards: TPSD1
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	1,259,008 bp[1]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• peptidase activity; • serine-type peptidase activity; • hydrolase activity; • serine-type endopeptidase activity;
Cellular component	• extracellular region; • extracellular;
Biological process	• proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	23430
	n/a
	ENSG00000095917
	n/a
	Q9BZJ3
	n/a
	NM_012217
	n/a
	NP_036349
	n/a
	Wikidata
View/Edit Human

Tryptase delta is an enzyme that in humans is encoded by the TPSD1 gene.[3][4]

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein.[4]

References

GRCh38: Ensembl release 89: ENSG00000095917 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Pallaoro M, Fejzo MS, Shayesteh L, Blount JL, Caughey GH (Feb 1999). "Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3". J Biol Chem. 274 (6): 3355–62. doi:10.1074/jbc.274.6.3355. PMID 9920877.
"Entrez Gene: TPSD1 tryptase delta 1".

Caughey GH (2006). "Tryptase genetics and anaphylaxis". J. Allergy Clin. Immunol. 117 (6): 1411–4. doi:10.1016/j.jaci.2006.02.026. PMC 2271076. PMID 16751005.
Caughey GH (2003). "New developments in the genetics and activation of mast cell proteases". Mol. Immunol. 38 (16–18): 1353–7. doi:10.1016/S0161-5890(02)00087-1. PMID 12217407.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wang HW, McNeil HP, Husain A, et al. (2002). "Delta tryptase is expressed in multiple human tissues, and a recombinant form has proteolytic activity". J. Immunol. 169 (9): 5145–52. doi:10.4049/jimmunol.169.9.5145. PMID 12391231.
Soto D, Malmsten C, Blount JL, et al. (2003). "Genetic deficiency of human mast cell alpha-tryptase". Clin. Exp. Allergy. 32 (7): 1000–6. doi:10.1046/j.1365-2222.2002.01416.x. PMID 12100045. S2CID 83740303.
Min HK, Kambe N, Schwartz LB (2001). "Human mouse mast cell protease 7-like tryptase genes are pseudogenes". J. Allergy Clin. Immunol. 107 (2): 315–21. doi:10.1067/mai.2001.112130. PMID 11174199.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000095917 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9920877-3] Pallaoro M, Fejzo MS, Shayesteh L, Blount JL, Caughey GH (Feb 1999). "Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3". J Biol Chem. 274 (6): 3355–62. doi:10.1074/jbc.274.6.3355. PMID 9920877.

[entrez-4] "Entrez Gene: TPSD1 tryptase delta 1".

Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic
Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator
Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase
Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin
Venombin	Ancrod Batroxobin
Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin/S1P4 Sedolisin/TPP1 Streptokinase Cathepsin A G

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

TPSD1

References

Further reading