The Brave Little Toaster to the Rescue

Rob McGoarty, the owner of the appliances and whom they refer to as "The Master", is in his last days of college and is working at a veterinary clinic. One night, while finishing on a thesis, his computer accidentally crashes due to a terrible computer virus. The appliances along with a rat named Ratso seek to help Rob by finding and reversing the effects of his computer virus, hence recovering the master's thesis. Meanwhile, Mack, Rob's lab assistant, plots to sell the injured animals Rob had been tending to as part of his courses, to a place in Santa Clarita called "Tartarus Laboratories", which is the same facility that Sebastian, an old monkey, was sent to when he was just a baby. When the appliances discover an old TLW-728 prototype radio named "Wittgenstein" abandoned, all alone and run-down in the basement when transistors were invented. Due to being infected by a computer virus, the same one that affected Rob's dorm room computer and the one in the vet's clinic lab when Wittgenstein tried to contact them earlier, the miserable supercomputer reveals that he is living on one rare vacuum tube, the WFC-11-12-55. The appliances learn that unless they find a replacement quickly, Wittgenstein's tube will blow and lead to his apparent death.

In an attempt to revive Wittgenstein to his superior state, Radio and Ratso go to the college's storage building to find the hard-to-find WFC-11-12-55 tube. However, when they come back for miles with the last apparent tube, which turns out to be the very rare tube they had been looking for, Radio and Ratso (after an argument with the tube) accidentally break it, and it seems that all hope is lost. Wittgenstein does his best with all his might, but the virus causes him to blow his remaining tube with an explosion, going dead. Ratso then blames Radio, and guilt-ridden over condemning the animals to their doom at Tartarus Laboratories, he gives up his own tube, thus sacrificing himself. Knowing that they were given a final chance to save the animals, the appliances replace the tube. With the boosted power of the new tube, Wittgenstein miraculously wakes up, regenerating all of his other tubes and destroying the viruses within him, allowing him to be completely revived as good as new. With the appliances and Wittgenstein's help, they alert Rob, his girlfriend Chris, the guard dogs, and they work together to stop Mack from selling the injured animals and have him arrested. After discovering the appliances in the truck, Rob and Chris assume that Mack had also planned to sell Rob's stuff as well. Later, they discover Wittgenstein in the basement along with Radio. Chris later replaces Radio's tube with a new one she found in Nome, reviving him. Wittgenstein is sold to a museum to be upgraded with modern technology. Wittgenstein has also restored Rob's thesis, to his delight. In the end all the animals are adopted to new owners except Ratso who Rob and Chris decide to keep as their pet, Rob proposes to Chris to which she accepts and they leave college with the appliances and Ratso hoping to start a new happy life.

• Deanna Oliver as Toaster, an inspiring Toastmaster pop-up two-slice toaster who is the leader of the clan of small appliances, Toaster is courageous, intelligent, kind, thoughtful and warmhearted.
• Timothy Stack as Lampy, an easily impressed yet slightly irascible gooseneck desktop lamp stand. He is bright, but tends to be ironically dimwitted, though he has a couple of good points.
• Roger Kabler as Radio, a wisecracking plastic line/battery-operated vacuum-tube-based prototype amplitude modulation radiotelegraphic alarm clock whose personality parodies loud and pretentious announcers.
• Eric Lloyd as Blanky, an electric blanket with an innocent demeanor.
• Thurl Ravenscroft as Kirby, a very deep-voiced, individualistic upright Kirby vacuum cleaner who dons a cynical, cantankerous attitude towards the other appliances. He is also the oldest appliance of the family.
• Brian Doyle-Murray as Wittgenstein, a TLW-728 prototype amplitude modulation radiotelegraphic supercomputer and the old brother of Radio. He is powered by a very rare cathode radio tube called the WFC-11-12-55. He was outmoded when transistors were invented. Later, he got a terrible virus that infected his tubes, causing him to not function properly anymore.
• Chris Young as Master Rob Minkoff-McGroarty, the original human owner of the five appliances. Now as an adult, he has left for the university.
• Jessica Tuck as Chris Caft, Rob's tomboyish, supportive girlfriend, nicknamed "Chris".
• Alfre Woodard as Maisie the Persian Cat, she is a sweet cat and protective of her three kittens, she initially did not like Ratso at all, but at the end of the film, she and him become good friends.
• Andy Milder as Ratso the Rat, a grumpy rat but with a good heart, at first he looks very grumpy and angry, as if he was angry about being kept as a pet, and does not believe that Rob is wonderful. This is possibly due to his past experiences with humans who yelled at him, threw things at him and called him to the exterminator. He is rude to almost everyone, but as the movie progresses, Ratso's heart begins to warm up with others.
• Jonathan Benair as Jim Bob, he is the assistant of Mack McCro, he and Mack plan to take the animals to Tartarus Laboratory but Mack and Jim are arrested by the Police.
• Eddie Bracken as Sebastian the Monkey, an old monkey who was the victim of the cruel experiments of Tartarus Laboratories and as a result has a mutilated and bandaged hand.
• Andrew Daly as Murgatroid the Snake, a friendly and good snake, He plays an important role since at one point, Jim Bob's truck goes through a few bumps in the road, breaking his glass tank, He then slips on Jim Bob and scares him. Finally, Mack and Jim are arrested. Back in Rob's laboratory, Chris reveals that Murgatroid will be installed in the reptile house at the zoo.
• Eddie Deezen as Charlie
• Paddi Edwards as Lab Computer
• Victoria Jackson as Mouse
• Marc Allen Lewis as Security Guard
• Ross Mapletoft as Modem
• Kevin Meaney as Apple the Apple Computer Macintosh-Series Model
• Jay Mohr as Mack McCro, he is the assistant of Rob McGroarty. Unlike the latter, he doesn't care about animals' feelings. In fact, he only cares about making money and intends to sell the animals (which Rob has been taking care of) to Tartarus Laboratories.
• Danny Nucci as Alberto the Dog, a Chihuahua dog with a broken leg and he speaks with a Mexican accent.
• Laurel Green as Campus Student
• Neil Ross as Security Camera and Police Man
• B.J. Ward as Police Lady
• Frank Welker as Dobermans
• Sandy Fox, Tom Kenny, Jill Talley, Susan Silo as Additional voices

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