True Jackson, VP

The show's main cast, from left to right: Danielle Bisutti, Matt Shively, Ashley Argota, Greg Proops, Keke Palmer, Ron Butler, and Robbie Amell

• Keke Palmer as True Jackson, a teenager who serves as the Vice President of the Youth Fashion Department at Mad Style, where she works, and gets into mishaps and has a lot of fun with her friends. She is intelligent, funny and hardworking with an odd family. She is usually the most sensible of her friends. In the beginning of the series, she has a crush on Jimmy, Mr. Madigan's nephew, and they eventually become a couple. In the series' finale, True becomes President after Mr. Madigan retires. A running gag in the series is when she says, "(you/she/he) (I/said/did) (there was) what now?".
• Ashley Argota as Lulu,[8] True's best friend and secretary–assistant. She tends to be very crazy, loud and clueless. She is easily distracted as seen in every episode. Although not many people believe it, she is very intelligent and loves math. She also suffers from trichophagia and she is also afraid of birds (as she mentions to True in one episode, "They give me the creeps but I'm not sure why"). Her last name was not revealed during the series. She has a boyfriend named Mikey J. She and Mikey J. share their first kiss in the series' finale.
• Matt Shively as Ryan Leslie Laserbeam, True's second best friend. Though he does not have an official job at Mad Style, he is always there to hang out with True and Lulu. He is not very intelligent and is very clumsy. Ryan's middle name is Leslie, but he dislikes it. Oscar is not sure if Laserbeam is Ryan's real last name, but according to Ryan's big brother, he got the name when one of his ancestors was given the name "Laserbeam" by his crew captain while he was working on a ship. It is hinted that he has a crush on Amanda, but this is no longer acknowledged in the second season due to his affection for Kelsey.
• Danielle Bisutti as Amanda Cantwell, one of the many workers at Mad Style. She is the Vice President of Women's Fashion. Through the beginning of the series, Amanda is seen as True's rival as they often fought/disagreed with each other, but Amanda is slowly becoming True's friend. She was not happy when she found out that Mr. Madigan hired a "kid". By the end of the series, though, she realizes that True isn't so bad and that she is actually looked up to.
• Robbie Amell as Jimmy Madigan, a mail deliverer at Mad Style, the nephew of Max Madigan, and the boy of True's affection. He has feelings towards True, but couldn't date her for a while due to a job rule, until True got jealous of a new mail girl and they became a couple. In the episode "True Secret", Jimmy and True are caught kissing by Max and he says that in order for them to stay together, one of them must quit. By the end of the episode, Max changes the rule. In the series' finale, he gets promoted to drummer of the staff lounge and Kelsey becomes the new mailroom girl.
• Ron Butler as Oscar, the main secretary and operator for Mad Style and works behind the reception desk on the floor where Mad Style offices are. He is seen taking calls on his headset or delivering messages to Amanda. Known to crack jokes, he tends to speak in a campy manner. He wears ascots all the time. Like Lulu, he does not have a last name. It is unknown what became of him after the series' finale, but it's assumed he remains as a secretary.
• Greg Proops as Max Madigan, the CEO of Mad Style and holds all the meetings and other social events, often glorifying True. He is eccentric and is Jimmy's uncle. He retires to stay at home with his wife Doris, who is pregnant with their first child. He can be quirky and confusing at times. Also, when stressed out, it isn't a good idea to get on his bad side. Over all, he is quite a fun person to work for.

• Dan Kopelman as Kopelman, a Mad Style employee that hardly speaks and is frequently ridiculed by Max.
• Jennette McCurdy as Amanda "Pinky" Turzo, True's archnemisis
• Trevor Brown as Mikey J, Lulu's boyfriend.
• Jordan Monaghan as Kelsey, Ryan's on-and-off girlfriend.
• Joy Osmanski as Ms. Patti Park, True's teacher.
• Melanie Paxson as Doris Madigan (née Aidem), Max Madigan's wife and True's school librarian.
• Taylor Parks as Shelly, one of True's friends.
• Vincent Ventresca as Mr. Jeff Jamerson, True's science teacher.
• Jo-Anne Krupa as Ella, the Mad Style accountant.

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  Filming location, Mad Style's New York fashion company and office, actually 1251 Avenue of the Americas

In August 2009, a line of clothing inspired by the show called "Mad Style by True Jackson" was released. The line was available exclusively at Walmart and is aimed at children and teens. This was the first line of clothing for the show and was a first for Nickelodeon releasing a line of clothing from one of their television shows. Commercials advertising the clothing line can be seen on Nickelodeon and TeenNick. Featured in the show and commercials is an instrumental version of the show's theme song.

A set of novels based on the show were released, via Amazon.[12]