U.S. Route 65 in Missouri

US 65 enters Missouri between the towns of Omaha, Arkansas and Ridgedale, Missouri. The road is a four-lane expressway, traveling through both Branson and Hollister towards Springfield. Through the Branson area, it is a freeway. North of Branson, the highway intersections with both westbound Route 76 (a freeway spur) and U.S. Route 160. All the way to Highlandville, U.S. 160 is the old alignment of U.S. 65 (until the 1960s).

U.S. Route 65 in Springfield

Just south of Route EE at the Highlandville exit, U.S. 65 returns to freeway status. The freeway is called "Schoolcraft Freeway" in Springfield, named in honor of Henry Rowe Schoolcraft. Also in Springfield, the highway has junctions with U.S. Route 60 (also known as James River Freeway) and Interstate 44 (I-44). The I-44 interchange includes a flyover ramp connecting northbound U.S. 65 with westbound I-44. Construction is completed that added two at U.S. 60. In September 2011, U.S. 65 became a six-lane divided freeway in Springfield between Interstate 44 and U.S. 60. It was the first six-lane highway in Southwest Missouri.[2] North of Springfield, it returns to a four-lane, non-interstate highway.

From Springfield to Buffalo, U.S. 65 has been upgraded as a four-lane non-interstate highway. This project began with the addition of a partial four-lane highway through the Fair Grove area to replace a dangerous traffic light intersection with an overpass. It culminated with the entire length of U.S. 65 becoming a four-lane highway from Springfield to just outside of Buffalo. The project was completed in summer 2010.

Through Buffalo, the highway now becomes two lanes with a center left-turn lane. This part of the highway has also seen upgrades in recent years, such as adding rumble strips and extending the middle turn lanes to just outside the city's northern portion.

From Buffalo to Preston, entering Hickory County, U.S. 65 remains a two-lane highway and has a four-way intersection with U.S. Route 54.

US 65 southbound from US 36 in Chillicothe

At Warsaw, the highway crosses over the western end of the Lake of the Ozarks and again becomes a four-lane non-interstate highway at the intersection with Route 7.

At Sedalia (where it is called Limit Avenue), it has an intersection with U.S. Route 50 (known locally as Broadway Blvd). At Marshall Junction, north of Sedalia in Saline County, U.S. 65 intersects with both Interstate 70 and U.S. Route 40. In Marshall (where it is called Lexington, Ave), U.S. 65 returns to two-lanes and stays so all the way up to Iowa. At Waverly, the highway becomes concurrent with U.S. Route 24 (which continues to Carrollton). Also in Waverly, U.S. 65 and U.S. 24 both cross the Missouri River on the Waverly Bridge. Further north, the road crosses U.S. Route 36 at Chillicothe and U.S. Route 136 at Princeton. The highway leaves Missouri at South Lineville and enters Iowa.

The section of highway from Preston to Marshall Junction has been cited as a good drive for motorcyclists, with its sparsely populated areas and the hilly landscape.[3]

From 1922 to 1926, US 65 in Missouri was known as Route 3. US 65 originally followed Route 248 and US 160 between Branson and Springfield. Route 3 was originally planned on a shorter route between Springfield and Preston, with Route 71 on the longer alignment via Buffalo, but Route 3 was quickly shifted east, absorbing Route 71.

All exits are unnumbered.

County	Location	mi[1]	km	Destinations	Notes
Taney	Oliver Township	0.000	0.000	US 65 south – Harrison	Continuation into Arkansas
		2.807	4.517	Route 86 west – Blue Eye
		5.570	8.964	Route 265 north – Table Rock Lake
	Hollister	8.850	14.243	US 65 Bus. / CR 165 north – Hollister	South end of freeway; southern terminus of US 65 Bus./CR 165; former Route 165
	Lake Taneycomo			Bridge
	Branson	11.447	18.422	Route 76 east / US 65 Bus. south (Main Street) / Seventy-six Country Blvd	South end of Route 76 overlap; northern terminus of US 65 Bus.; Seventy-six Country Blvd. is former Route 76 west
		12.407	19.967	Route 248 / Red Route west / CR 165 south (Shepherd of the Hills Expressway) Red Route east (Branson Landing Boulevard)	Diverging diamond interchange;[4] eastern terminus of Route 248; northern terminus of CR 165
		13.250	21.324	Branson Hills Parkway / Bee Creek Road
	Branson Township	16.142	25.978	Route 76 west (Ozark Mountain Highroad) / Route F	North end of Route 76 overlap; Ozark Mountain Highroad is former Route 465
	Jasper Township	18.756	30.185	US 160 – Reeds Spring, Forsyth	North end of freeway
		21.698	34.920	Route 176 east – Walnut Shade	Southern end of Route 176 overlap
		22.597	36.366	Route 176 west – Spokane	Northern end of Route 176 overlap
Christian	North Galloway Township	32.741	52.692	Route EE west – Highlandville	South end of freeway
	Ozark	37.001	59.547	US 65 Bus. north / Route F (South Street) – Sparta
		38.295	61.630	Route 14 – Billings, Ava
		41.513	66.809	Route J west / Route CC east – Air Park South
Greene	Springfield	43.622	70.203	Evans Road
		45.541	73.291	US 60 / US 65 Bus. north – Aurora, Seymour
		47.711	76.783	Battlefield Street
		49.249	79.259	Route D (Sunshine Street)
		51.274	82.518	US 65 Bus. south (Chestnut Expressway) – Springfield	Diverging diamond interchange[5]
		52.284	84.143	Route YY (Division Street)
		53.292	85.765	Route 744 (Kearney Street)	Former US 66
		54.079	87.032	I-44 west – Joplin I-44 east – St. Louis	Separate exits southbound; serves Springfield-Branson National Airport exits 82A-B
	North Campbell Township	54.809	88.207	County Road No. 102	North end of freeway; northbound exit and southbound entrance
	Fair Grove	64.869	104.397	Route 125 east / Route CC west – Fair Grove
Dallas	Sheridan Township	70.052	112.738	Route 215 west / Route O east – Olive, Pleasant Hope	Michigan left U-turn intersections
	Jackson Township	74.162	119.352	Route 38 east / Route TT west – Fair Grove, Marshfield
	Buffalo	83.153	133.822	Route 32 – Lebanon, Bolivar
		85.026	136.836	Route 73 north
	Louisburg	91.671	147.530	Route 64 east – Lebanon
Hickory	Preston	105.306	169.474	US 54 – Jefferson City, Nevada
Benton	Fristoe Township	124.044	199.629	Route 7 south – Climax Springs	Southern end of Route 7 overlap
	White Branch	128.063	206.097	Route 83 south – White Branch	South end of expressway
	Lake of the Ozarks			Bridge over the Osage River arm
	Warsaw	129.688	208.713	Warsaw	No direct northbound entrance
		130.249	209.615	Route 7 north – Warsaw, Clinton	Northern end of Route 7 overlap
		131.327	211.350	Truman Dam Access Road	North end of expressway
	Williams Township	146.378	235.573	Route 52 east – Cole Camp	Interchange; southern end of Route 52 overlap
Benton–Pettis county line	Williams–Flat Creek township line	151.426	243.697	Route 52 west – Windsor	Northern end of Route 52 overlap
Pettis	Sedalia	163.315	262.830	US 50 (Broadway Blvd) – Jefferson City, Kansas City, La Monte, Warrensburg, Knob Noster
		163.912	263.791	Route 765 east – Business District	Interchange; clockwise terminus of Route 765; northbound exit and southbound entrance
	Cedar Township	165.752	266.752	Route 765 south – Business District	Counterclockwise terminus of Route 765; no direct southbound entrance
Saline	Marshall Junction	181.887	292.719	I-70 east (US 40 east) – St. Louis	Cloverleaf interchange; I-70 exits 78A-B
				I-70 west (US 40 west) – Kansas City
	Marshall	190.141	306.002	US 65 Bus. north
		193.242	310.993	Route 20
		194.015	312.237	US 65 Bus. south / Route 240 east to Route 41
	Grand Pass Township	204.818	329.623	Route 127 south
Lafayette	Waverly	211.213	339.914	US 24 west – Waverly	Southern end of US 24 overlap
Missouri River				New Waverly Bridge (replaced old Waverly Bridge in 2004)
Carroll	Carrollton	220.839	355.406	US 65 Bus. north / Route 10 west
		222.526	358.121	US 24 east / US 65 Bus. south	Northern end of US 24 overlap
Livingston	Chillicothe	253.257	407.578	US 36 / Route 110 (CKC) – Brookfield, Hamilton US 36 Bus. begins	Interchange with the CKC; southern end of US 36 Bus. overlap
		253.359	407.742	US 36 Bus. east	Northern end of US 36 Bus. overlap
		256.428	412.681	Route 190 west
Grundy	Trenton	276.310	444.678	US 65 Bus. north / Route 6 – Trenton, Milan
		277.384	446.406	US 65 Bus. south
Mercer	Princeton	299.403	481.842	US 136 east – Unionville	Southern end of US 136 overlap
		299.731	482.370	US 136 west – Bethany	Northern end of US 136 overlap
	South Lineville	313.114	503.908	US 65 north – Lineville	Continuation into Iowa
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Incomplete access

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U.S. Route 65
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