(-)-menthol monooxygenase
In enzymology, a (−)-menthol monooxygenase (EC 1.14.13.46) is an enzyme that catalyzes the chemical reaction
- (−)-menthol + NADPH + H+ + O2 p-menthane-3,8-diol + NADP+ + H2O
| (−)-menthol monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.46 | ||||||||
| CAS number | 117590-75-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 4 substrates of this enzyme are (−)-menthol, NADPH, H+, and O2, whereas its 3 products are p-menthane-3,8-diol, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is (−)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating). This enzyme is also called l-menthol monooxygenase.
Uses
Use of (−)-menthol monooxygenase has been explored by several companies including Procter & Gamble for cleaning products.[1] [2] [3]
References
- "Cleaning compositions comprising a specific oxygenase"|Alfons, Ivan Maurice et al.|https://patents.google.com/patent/EP1002040B2/en
- "Methods for conducting assays for enzyme activity on protein microarrays"|Zhou, Fang X.; Schweitzer, Barry| https://patents.google.com/patent/US7635572B2/en?oq=US7635572B2
- "Cleaning compositions contain a specific oxygenase"|Barnabas, Mary et al.|https://patents.google.com/patent/DE69727704T3/en
- Madyastha KM, Srivatsan V (1988). "Studies on the metabolism of l-menthol in rats". Drug Metab. Dispos. 16 (5): 765–72. PMID 2906604.