EGLN2

Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 gene.[5] ELGN2 is an alpha-ketoglutarate-dependent hydroxylase, a superfamily of non-haem iron-containing proteins.

EGLN2
Identifiers
AliasesEGLN2, EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1, egl-9 family hypoxia inducible factor 2, EIT-6
External IDsOMIM: 606424 MGI: 1932287 HomoloGene: 14204 GeneCards: EGLN2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.2Start40,798,996 bp[1]
End40,808,434 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

112398

112406

Ensembl

ENSG00000269858

ENSMUSG00000058709

UniProt

Q96KS0

Q91YE2

RefSeq (mRNA)

NM_080732
NM_017555
NM_053046

NM_053208
NM_001357767

RefSeq (protein)

NP_444274
NP_542770

NP_444438
NP_001344696

Location (UCSC)Chr 19: 40.8 – 40.81 MbChr 7: 27.16 – 27.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degradation by prolyl hydroxylation. This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000269858 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000058709 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: EGLN2 egl nine homolog 2 (C. elegans)".

Further reading


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