FMO2

Dimethylaniline monooxygenase [N-oxide-forming] 2 is an enzyme that in humans is encoded by the FMO2 gene.[5][6][7]

FMO2
Identifiers
AliasesFMO2, FMO1B1, flavin containing monooxygenase 2, flavin containing dimethylaniline monoxygenase 2
External IDsOMIM: 603955 MGI: 1916776 HomoloGene: 86882 GeneCards: FMO2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q24.3Start171,185,249 bp[1]
End171,212,686 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2327

55990

Ensembl

ENSG00000094963

ENSMUSG00000040170

UniProt

Q99518

Q8K2I3

RefSeq (mRNA)

NM_001301347
NM_001460
NM_001365900

NM_018881
NM_001360913
NM_001360914

RefSeq (protein)

NP_001288276
NP_001451
NP_001352829

NP_061369
NP_001347842
NP_001347843

Location (UCSC)Chr 1: 171.19 – 171.21 MbChr 1: 162.87 – 162.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in humans, this enzyme is truncated and is probably rapidly degraded. The protein encoded by this gene represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000094963 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040170 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dolphin CT, Shephard EA, Povey S, Smith RL, Phillips IR (Nov 1992). "Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family". Biochem J. 287. ( Pt 1): 261–7. doi:10.1042/bj2870261. PMC 1133153. PMID 1417778.
  6. Dolphin CT, Beckett DJ, Janmohamed A, Cullingford TE, Smith RL, Shephard EA, Phillips IR (Dec 1998). "The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein". J Biol Chem. 273 (46): 30599–607. doi:10.1074/jbc.273.46.30599. PMID 9804831.
  7. "Entrez Gene: FMO2 flavin containing monooxygenase 2 (non-functional)".

Further reading


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