2005 National League Championship Series

Houston won the series, 4–2.

Wednesday, October 12, 2005 at Busch Stadium (II) in St. Louis, Missouri

The Cardinals struck first in Game 1 when David Eckstein hit a leadoff single in the first off of starter Andy Pettitte, who was struck by a batted ball during batting practice but made the start as scheduled, then Reggie Sanders's home run two outs later put them up 2−0. Mark Grudzielanek singled to lead off the second, moved to third on Abraham Nunez's single one out later, and scored on Chris Carpenter's sacrifice bunt. In the fifth, Nunez again hit a leadoff single, moved to second on a sacrifice bunt, and scored on Eckstein's single with Eckstein reaching second on right fielder Jason Lane's throw to home. One out later, Albert Pujols's RBI single made it 5−0 Cardinals. Carpenter pitched six shutout innings before pinch hitter Chris Burke's two-run home run put the Astros on the board in the seventh. Brad Ausmus's sacrifice fly in the ninth off of Jason Isringhausen made it 5−3 Cardinals before pinch hitter Jose Vizcaino grounded out to end the game as the Cardinals went up 1−0 in the series.

Thursday, October 13, 2005 at Busch Stadium (II) in St. Louis, Missouri

The Astros struck first in Game 2 when Chris Burke tripled with one out in the second and scored on a passed ball by starter Mark Mulder. In the fifth, Brad Ausmus hit a leadoff double, moved to third on Roy Oswalt's sacrifice bunt and scored on Craig Biggio's ground out. Albert Pujols's leadoff home run off of Oswalt in the sixth put the Cardinals on the board, but they would get nothing more. The Astros scored two insurance runs in the eighth off of Julián Tavárez on Chris Burke's RBI single that scored Lance Berkman from third. followed by Adam Everett's RBI triple. Brad Lidge pitched two shutout innings for the save as the Astros' 4−1 win tied the series at 1−1 heading to Houston.

Saturday, October 15, 2005 at Minute Maid Park in Houston, Texas

In Game 3, Cardinals' starter Matt Morris pitched three shutout innings before walking Morgan Ensberg to lead off the fourth, then Mike Lamb's home run put the Astros up 2−0. In the fifth, the Astros' Roger Clemens allowed back-to-back leadoff singles to Yadier Molina and Abraham Nunez. Morris's sacrifice bunt moved them up one base each before David Eckstein's sacrifice fly put the Cardinals on the board. Clemens again allowed back-to-back leadoff singles next inning to Albert Pujols and Jim Edmonds before Larry Walker's sacrifice fly tied the game. In the bottom of the inning, Lamb hit a one-out double and scored on Jason Lane's single. After Brad Ausmus singled, Brad Thompson relieved Morris and Adam Everett hit into a fielder's choice that allowed Lane to score to put the Astros up 4−2. Chad Qualls pitched two hitless innings before Brad Lidge retired the first two batters in the ninth and walked John Rodriguez. Rodriguez then moved to second on defensive indifference before scoring on John Mabry's double. This is the first run Lidge allowed against the Cardinals since May 29, 2003, but held on for the save to give the Astros a 2–1 series lead. It was Clemens' 12th career postseason win, fifth in League Championship Series games.

Sunday, October 16, 2005 at Minute Maid Park in Houston, Texas

Brandon Backe provided a strong outing, and the Astro bullpen continued its strong performance. The Cardinals struck first in the fourth when David Eckstein drew a leadoff walk, moved to third on Jim Edmonds's double, and scored on Albert Pujols's sacrifice fly, but the Astros tied in the bottom of the inning on Jason Lane's home run off of Jeff Suppan. The Astros loaded the bases in the seventh off of Jason Marquis on two walks and an error when Morgan Ensberg's sacrifice fly put them up 2−1. Tony La Russa and Jim Edmonds were both ejected for arguing balls and strikes on separate instances—LaRussa in the bottom of the seventh, Edmonds in the top of the eighth, at a key moment. Edmonds's ejection came with a 3–2 count, two outs, and a runner on base. Edmonds was replaced by pinch hitter John Rodríguez, who flied out to deep center field to end the scoring threat. The Cardinals once again had an opportunity to tie the game or take the lead in the ninth inning against closer Brad Lidge. Albert Pujols and Larry Walker led off the inning with back-to-back singles, putting runners at first and third base with no outs. Reggie Sanders grounded to third; Pujols went home on contact and was thrown out at the plate. Larry Walker advanced to third when the Astros failed to call timeout after the play at the plate. John Mabry ended the threat by grounding into a double play. La Russa's ejection marked the first time a manager was ejected from a postseason game since 1998, when Mike Hargrove was thrown out of a game between his Cleveland Indians and the New York Yankees. Houston was one game away from the franchise's first visit to the World Series after a 2–1 Game 4 win.

Monday, October 17, 2005 at Minute Maid Park in Houston, Texas

The Astros struck first in Game 5 on Craig Biggio's RBI single in the second off of starter Chris Carpenter, but the Cardinals loaded the bases on two hits and a walk off of Andy Pettitte when Mark Grudzielanek's two-run single put them up 2–1. Lance Berkman gave excited Astros fans a 4–2 lead with one swing on a pitch from Carpenter in the bottom of the seventh inning. The Astros were one strike away from claiming their first NL Pennant and trip to the Fall Classic before David Eckstein singled with no one on base, Jim Edmonds walked, and Albert Pujols hit a dramatic, towering three-run home run off Astros closer Brad Lidge that bounced off the side of the closed Minute Maid Park roof before landing on the railroad tracks in left field, stunning the crowd into silence. The home run gave the Cardinals a 5–4 lead in the top of the ninth inning. Jason Isringhausen retired the Astros in order in the bottom of the inning. The Cardinals guaranteed that another game would be played at historic Busch Stadium (II). The win also broke the Cardinals' seven-game losing streak in road NLCS games. The Astros' series lead was trimmed to 3-2.

Wednesday, October 19, 2005 at Busch Stadium (II) in St. Louis, Missouri

The Astros shook off the effects of their Game 5 loss, and rolled to win their first National League pennant in 44 seasons of existence with a decisive 5–1 win over the Cardinals. The Astros scored a run in the third when the Cardinals' Mark Mulder threw a wild pitch to Craig Biggio with runners on second and third, then Biggio's RBI single scored another. Jason Lane's home run in the fourth put them up 3−0. Roy Oswalt pitched seven strong innings, allowing only a sacrifice fly to John Rodriguez in the fifth. The Astros scored one run in the sixth on Adam Everett's sacrifice bunt off of Jason Marquis and another in the seventh on Morgan Ensberg's RBI single off of Julián Tavárez. This was the final game at Busch Stadium (II). This would also be the Astros' last postseason win as a member of the NL, as they would get swept in the World Series, move to the AL in 2013, and would not win another postseason game until the 2015 American League Wild Card Game.

Roy Oswalt was named the series MVP. In two starts, he went 2–0 with a 1.29 ERA in 14 innings.