2006 National League Division Series

New York won the series, 3–0.

St. Louis won the series, 3–1.

Shea Stadium in Queens, New York

The game started off with Mets rookie starter John Maine on the mound as an emergency replacement for Orlando Hernández. Hernández was sidelined with a torn muscle, and ended up missing the rest of the postseason. Maine kept the Mets in the game with only one earned run in ​4 ¹⁄₃ innings pitched. This game was notable for having two runners getting tagged out at home plate in the second inning. With runners on first and second and nobody out, catcher Russell Martin hit a line drive to the wall in right field. Jeff Kent tried to tag up from second base in the event that right fielder Shawn Green caught the ball. Instead, the ball sailed over Green's head. Both Kent and J. D. Drew raced around the bases towards the plate. Green threw to cut-off man José Valentín, who relayed to Paul Lo Duca at the plate. Lo Duca was first able to tag out Kent. Drew, trying to score in desperation right behind Kent, was also tagged out at the plate. Lo Duca almost did not see Drew in time to slap the tag on. Martin would score on Marlon Anderson's double but Carlos Delgado and Cliff Floyd hit solo home runs in the fourth off of Derek Lowe. Lo Duca and Delgado singled in the sixth before scoring on David Wright's double to make it 4–1 Mets. In the seventh, Anderson hit a leadoff single off of Guillermo Mota and second baseman Valetin's error on Wilson Betemit's ground ball put runners on first and third with no outs for the Dodgers. After Julio Lugo struck out, Anderson scored on Rafael Furcal's single. After Furcal stole second, Nomar Garciaparra's two-out double tied the game,. In the bottom of the inning, reliever Brad Penny walked two with one out before Delgado's single and Wright's double scored a run each. In the ninth, closer Billy Wagner allowed a leadoff double to Betemit, who scored on Ramon Martinez's two-out double, but Garciaparra struck out to end the game as the Mets took a 1–0 series lead.

Shea Stadium in Queens, New York

Game 2 pitted Dodgers rookie Hong-Chih Kuo against Tom Glavine. In the bottom of the third, outfielder Endy Chávez hit a bunt single to lead off the inning. A wild pitch and subsequent ground out moved him to third before he scored on José Reyes's ground out. In the fifth, the Mets loaded the bases on a hit and two walks with one out off of Kuo, who was then relieved by Brett Tomko. Paul Lo Duca's sacrifice fly gave the Mets a 2–0 lead. In the sixth, the Mets loaded the bases again on two hits and an error with no outs. Mark Hendrickson relieved Tomko and got Endy Chavez to hit into a force out at home. Pinch-hitter Julio Franco's fielder's choice and Reyes's RBI single scored a run each. Wilson Betemit hit a home run in the eighth off of Aaron Heilman for the Dodgers but Wagner pitched a perfect ninth for his second save of the series. The Dodgers were hit with more bad news. Nomar Garciaparra was lost after a leg injury that would keep him off the field except for pinch-hitting duties.

Dodger Stadium in Los Angeles, California

In Los Angeles, the Mets loaded the bases in the first with one out on a walk and two singles off of veteran starter Greg Maddux before RBI singles by David Wright, Cliff Floyd and Shawn Green put them up 3–0. In the third, Floyd singled with two outs before scoring on Green's double. In the fourth, the Dodgers loaded the bases on three singles off of Mets starter Steve Trachsel with one out before rookie first baseman James Loney, starting in place of the injured Nomar Garciaparra, drove in two with a single to center. In the fifth, Marlon Anderson singled with two outs before Jeff Kent's home run off reliever Darren Oliver tied the game at four. After allowing a single to J. D. Drew, Oliver was relieved by Chad Bradford, who allowed a single and walk to load the bases. Pedro Feliciano relieved Bradford and walked Loney to put the Dodgers up 5–4. In the top of the sixth, Shawn Green hit a leadoff double off of Jonathan Broxton. After José Valentín popped out on the infield, pinch hitter Michael Tucker drew a walk. Three consecutive bloop hits from José Reyes, Paul Lo Duca, and Carlos Beltrán scored a run each, making it 7–5 Mets. Chris Woodward doubled to lead off the eighth off of Brett Tomko and scored on Lo Duca's one-out single. After a walk, Takashi Saito relieved Tomko and an error on Carlos Delgado's ground ball made it 9–5 Mets. Aaron Heilman and Billy Wagner pitched a scoreless eighth and ninth, respectively, as the Mets swept a postseason series for the first time since the 1969 NLCS. Former Dodgers Green and Lo Duca finished with two RBI each.

2006 NLDS (3–0): New York Mets over Los Angeles Dodgers

Petco Park in San Diego, California

In a pitching rematch of Game 1 of the 2005 NLDS, Chris Carpenter and Jake Peavy both started strong through three innings and it appeared that the pitcher's duel that was expected the previous year would occur this time around. That changed in the fourth inning when Chris Duncan hit a leadoff single, then Albert Pujols hit a two-run home run 422 feet (129 m) into one of the deepest parts of Petco Park. Jim Edmonds then singled, moved to third on Scott Rolen's double, and scored on Juan Encarnación's sacrifice fly. The Cardinals added to their lead on Edmonds's RBI single next inning that scored David Eckstein from third and in the sixth when Ronnie Belliard singled with one out, stole second, and scored on Yadier Molina's single to knock Peavy out of the game. Carpenter, on the other hand, continued his strong pitching performance as he pitched into the seventh inning, allowing just one run to cross the plate when Dave Roberts tripled with one out in the sixth and scored on Brian Giles's sacrifice fly. The Cardinal bullpen, which had been shaky down the stretch, pitched the final ​2 ²⁄₃ innings of the game allowing just one hit. The Cardinals led the best-of-five series one game to none.[9]

Petco Park in San Diego, California

Cardinal starter Jeff Weaver and four relievers combined on a four-hitter to shut out the Padres 2–0. The only runs scored in the game came in the fourth when Preston Wilson hit a leadoff double and scored on a single by Albert Pujols, who reached second on Dave Roberts's throw to home. Pujols moved to third on a groundout before scoring on Jim Edmonds's RBI single. Padres starter David Wells pitched five solid innings in a losing effort.

Busch Stadium (III) in St. Louis, Missouri

Game 3 ended the Padres' eight-game winless streak against the Cardinals in the postseason and gave them their first postseason win since Game 6 of the 1998 NLCS. However, they left 14 runners on base. The Padres scored their runs in the third off of Jeff Suppan when he allowed a one-out double to Adrián González and walked Mike Cameron before both men scored on Russell Branyan's double to left, with Branyan reaching third on Chris Duncan's throw to home. Branyan then scored on Geoff Blum's sacrifice fly. The Cardinals scored their only run in the eighth on So Taguchi's home run off of reliever Scott Linebrink.

As of 2019, this was the last postseason win for the Padres.

Busch Stadium (III) in St. Louis, Missouri

After losing Game 3, Cardinals manager Tony La Russa decided to use Carpenter to start Game 4 in hopes of closing out the Series at home. Carpenter started off shakily, allowing back-to-back one hit singles to Brian Giles and Adrián González and walking Josh Bard to load the bases. Russell Branyan walked to force in a run before Mike Cameron's groundout scored another. Carpenter settled down and pitched six scoreless innings before being pulled in the eighth.

St. Louis answered by loaded the bases in the bottom of the inning off of Woody Williams on a single, walk and hit-by-pitch with two outs before Ronnie Belliard tied the game with a two-run single, but was tagged out at second to end the inning. The game remained tied until the seventh when Albert Pujols drew a leadoff walk and scored on Juan Encarnación's triple. Williams was replaced with Cla Meredith, who hit Belliard with a pitch before allowing an RBI single to Scott Spiezio. Yadier Molina's single loaded the bases before Padre third baseman Branyan's throwing error to second on Carpenter's ground ball scored Belliard and kept the bases loaded. David Eckstein's sacrifice bunt scored Spiezio to give the Cardinals a 6–2 lead. Rookie pitcher Adam Wainwright pitched a scoreless ninth despite allowing two hits to close out the Series and allow the Cardinals to advance to the NLCS for the third consecutive year.

The offensive woes that plagued the Padres in the first three games continued for the Padres in Game 4. The team failed to score after the first, and went a combined 2-for-32 with runners in scoring position in the Series.

It was the final Division Series game televised by Fox, at least for the foreseeable future. This was the last playoff game for the Padres, until 2020.

2006 NLDS (3–1): St. Louis Cardinals over San Diego Padres