Major League Baseball on ESPN Radio

As previously mentioned, in beginning in the 1998 season, ESPN Radio took over from CBS Radio as the official, national radio broadcaster for Major League Baseball. The network's contract with MLB currently runs through 2021, and as of 2006, Major League Baseball on ESPN Radio is heard on over 321 stations across the United States.

The games include Opening Day, Sunday Night Baseball, Saturday Game of the Week (usually the same matchup as the Sunday Night game), holiday games and September pennant race games. ESPN Radio holds exclusive radio rights to the All-Star Game and Home Run Derby. The postseason (including the Wild Card Games, Division Series, League Championship Series and World Series) is a semi-exclusive arrangement. The participating teams' flagship stations are allowed to air play-by-play using their own announcers and production. The national ESPN Radio feed may, however, be carried live on another station in those markets as well (for instance, WHB in Kansas City aired the ESPN feed of Kansas City Royals postseason games in 2014 and 2015, competing directly with the Royals Radio Network broadcast on KCSP). If affiliate stations on the teams' radio networks wish to carry coverage of postseason games they must use the national feed. Since the inaugural World Baseball Classic in March 2006, the semi-finals and the championship have also been broadcast as part of Major League Baseball on ESPN Radio.

In addition to affiliate stations on AM/FM radio, ESPN Radio's game broadcasts are carried as part of Sirius XM Radio's MLB coverage (with Sunday night games also being simulcast on MLB Network Radio). However, they are not included in the subscription "Gameday Audio" package on MLB.com with the exception of the All-Star Game, for which no other radio play-by-play feed is available.

Since June 2011, the games can also be heard online at ESPN Radio.com and on mobile devices via the ESPN app and other applications such as TuneIn. They can also be heard on televisions using connected devices (such as video game consoles) via their respective iHeartRadio and Tunein apps. Previously, rights restrictions prevented ESPN Radio.com from live-streaming the games.

As of 2011, the primary ESPN Radio crew for Sunday Night Baseball consists of play-by-play announcer Jon Sciambi and color analyst Chris Singleton. In 2010, Sciambi succeeded Gary Thorne, who had called play-by-play in 2008–09; Thorne had succeeded Dan Shulman, did so from 2002 to 2007; Shulman, in turn, had been preceded by Charley Steiner from 1998 to 2002. Singleton succeeded Dave Campbell, who was an analyst from 1999 to 2010. Campbell replaced Kevin Kennedy as analyst in 1999, after the latter had worked with Steiner in the network's inaugural season of coverage. Marc Kestecher currently serves as the network's primary Baseball Tonight studio host; he was preceded by Joe D'Ambrosio from 1998 to 2007.

As of 2018, Dan Shulman calls the World Series and one of the two League Championship Series with Singleton each year (Jessica Mendoza joined this crew in 2020), while Sciambi calls the other LCS with Mendoza. Various other announcers work the network's secondary regular-season, Wild Card Game and Division Series broadcasts as needed. Sciambi and Singleton also call the All-Star Game and Home Run Derby each year.

For the 2020 season, due to the COVID-19 pandemic, Sciambi and Singleton called each game remotely from their respective homes rather than at the ballpark. For the 2020 postseason, they and all of ESPN Radio's announcers called the games from the ESPN studios in Bristol, Connecticut.