4-nitrophenylphosphatase

In enzymology, a 4-nitrophenylphosphatase (EC 3.1.3.41) is an enzyme that catalyzes the chemical reaction

4-nitrophenyl phosphate + H2O 4-nitrophenol + phosphate
4-nitrophenylphosphatase
Identifiers
EC number3.1.3.41
CAS number9073-68-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 4-nitrophenyl phosphate and H2O, whereas its two products are 4-nitrophenol and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 4-nitrophenylphosphate phosphohydrolase. Other names in common use include nitrophenyl phosphatase, p-nitrophenylphosphatase, para-nitrophenyl phosphatase, K-pNPPase, NPPase, PNPPase, Ecto-p-nitrophenyl phosphatase, and p-nitrophenylphosphate phosphohydrolase. This enzyme participates in gamma-hexachlorocyclohexane degradation.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 1VJR.

References

    • Attias J, Bonnet JL (1972). "A specific alkaline p-nitrophenylphosphatase activity from baker's yeast". Biochim. Biophys. Acta. 268 (2): 422–30. doi:10.1016/0005-2744(72)90338-5. PMID 4554643.
    • Attias J, Durand H (1973). "Further characterization of a specific p-nitrophenylphosphatase from baker's yeast". Biochim. Biophys. Acta. 321 (2): 561–8. doi:10.1016/0005-2744(73)90199-x. PMID 4357666.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.