Inositol monophosphatase 3

BPNT2
Identifiers
Aliases	BPNT2, GPAPP, IMP 3, IMP-3, IMPA3, inositol monophosphatase domain containing 1, IMPAD1, 3'(2'), 5'-bisphosphate nucleotidase 2
External IDs	OMIM: 614010 MGI: 1915720 HomoloGene: 9852 GeneCards: BPNT2
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	56,993,867 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	4,793,355 bp[2]
Gene ontology
Molecular function	• inositol monophosphate 1-phosphatase activity; • inositol monophosphate 4-phosphatase activity; • hydrolase activity; • inositol monophosphate phosphatase activity; • metal ion binding; • inositol monophosphate 3-phosphatase activity; • 3'-nucleotidase activity; • 3'(2'),5'-bisphosphate nucleotidase activity;
Cellular component	• integral component of membrane; • membrane; • Golgi apparatus; • cell nucleus; • cytosol; • nuclear body; • Golgi lumen;
Biological process	• skeletal system development; • chondrocyte development; • embryonic digit morphogenesis; • phosphatidylinositol phosphorylation; • chondroitin sulfate metabolic process; • endochondral ossification; • post-embryonic development; • inositol biosynthetic process; • dephosphorylation; • 3'-phosphoadenosine 5'-phosphosulfate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	54928
	242291
	ENSG00000104331
	ENSMUSG00000066324
	Q9NX62
	Q80V26
	NM_017813
	NM_177730
	NP_060283
	NP_808398
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol monophosphatase 3 also known as inositol monophosphatase domain-containing protein 1 (IMPAD1) is an enzyme that in humans is encoded by the IMPAD1 gene.[5]

This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP).[5]

Clinical significance

Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1.[5]

References

GRCh38: Ensembl release 89: ENSG00000104331 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000066324 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Inositol monophosphatase domain containing 1".

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104331 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066324 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Inositol monophosphatase domain containing 1".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)