ADCY8

Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.[4][5]

ADCY8
Identifiers
AliasesADCY8, AC8, ADCY3, HBAC1, adenylate cyclase 8 (brain), adenylate cyclase 8
External IDsOMIM: 103070 MGI: 1341110 HomoloGene: 37443 GeneCards: ADCY8
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q24.22Start130,780,301 bp[1]
End131,040,909 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

114

11514

Ensembl

ENSG00000155897

ENSMUSG00000022376

UniProt

P40145
Q4F7X0

P97490

RefSeq (mRNA)

NM_001115

NM_001291903
NM_009623
NM_001331075

RefSeq (protein)

NP_001106
NP_001106.1

NP_001278832
NP_001318004
NP_033753

Location (UCSC)Chr 8: 130.78 – 131.04 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000155897 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J (Aug 1994). "Molecular cloning of the human type VIII adenylyl cyclase". FEBS Letters. 351 (1): 109–13. doi:10.1016/0014-5793(94)00836-1. PMID 8076676. S2CID 7559521.
  5. "Entrez Gene: ADCY8 adenylate cyclase 8 (brain)".

Further reading


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