Cytidylate cyclase

In enzymology, a cytidylate cyclase (EC 4.6.1.6) is an enzyme that catalyzes the chemical reaction

CTP 3',5'-cyclic CMP + diphosphate
cytidylate cyclase
Identifiers
EC number4.6.1.6
CAS number65357-82-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, CTP, and two products, 3',5'-cyclic CMP and diphosphate.

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming). Other names in common use include 3',5'-cyclic-CMP synthase, cytidylyl cyclase, cytidyl cyclase, and CTP diphosphate-lyase (cyclizing).

References

    • Cech SY, Ignarro LJ (1978). "Cytidine 3',5'-monophosphate (cyclic CMP) formation by homogenates of mouse liver". Biochem. Biophys. Res. Commun. 80 (1): 119–25. doi:10.1016/0006-291X(78)91112-9. PMID 23778.
    • JH (1985). "3',5'-Cyclic UMP, -cyclic IMP, -cyclic TMP and related enzymes in mammalian-tissues". Biochem. Soc. Trans. 13: 1134–1135.


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