NPR2

NPR2
Identifiers
Aliases	NPR2, AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK, natriuretic peptide receptor 2
External IDs	OMIM: 108961 MGI: 97372 HomoloGene: 2970 GeneCards: NPR2
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	35,809,732 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	43,651,244 bp[2]
Gene ontology
Molecular function	• protein kinase activity; • nucleotide binding; • hormone binding; • GTP binding; • lyase activity; • identical protein binding; • phosphorus-oxygen lyase activity; • ATP binding; • guanylate cyclase activity; • natriuretic peptide receptor activity; • peptide hormone binding; • GO:0001948 protein binding; • adenylate cyclase activity; • peptide receptor activity;
Cellular component	• integral component of membrane; • membrane; • cell membrane; • guanylate cyclase complex, soluble; • integral component of plasma membrane; • intracellular;
Biological process	• negative regulation of meiotic cell cycle; • regulation of cardiac conduction; • GO:0007243 intracellular signal transduction; • ossification; • negative regulation of oocyte maturation; • cyclic nucleotide biosynthetic process; • regulation of blood pressure; • cGMP biosynthetic process; • protein phosphorylation; • cellular response to granulocyte macrophage colony-stimulating factor stimulus; • bone development; • receptor guanylyl cyclase signaling pathway; • reproductive process; • positive regulation of cGMP-mediated signaling; • cGMP-mediated signaling; • signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4882
	230103
	ENSG00000159899
	ENSMUSG00000028469
	P20594
	Q6VVW5
	NM_000907; NM_003995
	NM_173788; NM_001355466
	NP_003986; NP_001365852
	NP_776149; NP_001342395
	Wikidata
View/Edit Human	View/Edit Mouse

Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B), also known as NPR2, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR2 gene.[5]

References

GRCh38: Ensembl release 89: ENSG00000159899 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028469 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)".

Fox AA, Collard CD, Shernan SK, et al. (2009). "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting". Anesthesiology. 110 (4): 738–47. doi:10.1097/ALN.0b013e31819c7496. PMC 2735337. PMID 19326473.
Potthast R, Abbey-Hosch SE, Antos LK, et al. (2004). "Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B". J. Biol. Chem. 279 (47): 48513–9. doi:10.1074/jbc.M408247200. PMID 15371450.
Liew D, Schneider H, D'Agostino J, et al. (2004). "Utility of B-type natriuretic peptide as a screen for left ventricular dysfunction in patients with diabetes: response to Epshteyn et al". Diabetes Care. 27 (3): 848, author reply 848–9. doi:10.2337/diacare.27.3.848. PMID 14988324.
Antos LK, Abbey-Hosch SE, Flora DR, Potter LR (2005). "ATP-independent activation of natriuretic peptide receptors". J. Biol. Chem. 280 (29): 26928–32. doi:10.1074/jbc.M505648200. PMID 15911610.
Poreba R; Poczatek K; Gać P; et al. (2009). "SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension". Pol. Arch. Med. Wewn. 119 (4): 219–24. PMID 19413180.
Koller KJ, Goeddel DV (1992). "Molecular biology of the natriuretic peptides and their receptors". Circulation. 86 (4): 1081–8. doi:10.1161/01.cir.86.4.1081. PMID 1327579.
Fan D, Bryan PM, Antos LK, et al. (2005). "Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize". Mol. Pharmacol. 67 (1): 174–83. doi:10.1124/mol.104.002436. PMID 15459247. S2CID 53520.
Pagel-Langenickel I, Buttgereit J, Bader M, Langenickel TH (2007). "Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy". J. Mol. Med. 85 (8): 797–810. doi:10.1007/s00109-007-0183-4. PMID 17429599. S2CID 42834676.
Rahmutula D, Cui J, Chen S, Gardner DG (2004). "Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1". Hypertension. 44 (3): 283–8. doi:10.1161/01.HYP.0000136908.60317.92. PMID 15262909.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Hume AN, Buttgereit J, Al-Awadhi AM, et al. (2009). "Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux". Hum. Mol. Genet. 18 (2): 267–77. doi:10.1093/hmg/ddn354. PMC 2638773. PMID 18945719.
Schulz S (2005). "C-type natriuretic peptide and guanylyl cyclase B receptor". Peptides. 26 (6): 1024–34. doi:10.1016/j.peptides.2004.08.027. PMID 15911070. S2CID 24299700.
Tsuji T, Kunieda T (2005). "A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse". J. Biol. Chem. 280 (14): 14288–92. doi:10.1074/jbc.C500024200. PMID 15722353.
Dickey DM, Yoder AR, Potter LR (2009). "A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation". J. Biol. Chem. 284 (29): 19196–202. doi:10.1074/jbc.M109.010777. PMC 2740543. PMID 19458086.
Nozohoor S, Nilsson J, Lührs C, et al. (2009). "B-type natriuretic peptide as a predictor of postoperative heart failure after aortic valve replacement". J. Cardiothorac. Vasc. Anesth. 23 (2): 161–5. doi:10.1053/j.jvca.2008.11.006. PMID 19167912.
Hachiya R, Ohashi Y, Kamei Y, et al. (2007). "Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development". J. Clin. Endocrinol. Metab. 92 (10): 4009–14. doi:10.1210/jc.2007-1101. PMID 17652215.
Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bartels CF, Bükülmez H, Padayatti P, et al. (2004). "Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux". Am. J. Hum. Genet. 75 (1): 27–34. doi:10.1086/422013. PMC 1182004. PMID 15146390.
van den Akker F (2001). "Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors". J. Mol. Biol. 311 (5): 923–37. doi:10.1006/jmbi.2001.4922. PMID 11556325.

External links

NPR2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159899 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028469 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

NPR2

See also

References

Further reading

External links