GUCY1A3

Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.[5][6]

GUCY1A1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGUCY1A1, GC-SA3, GUC1A3, GUCA3, GUCSA3, MYMY6, guanylate cyclase 1, soluble, alpha 3, guanylate cyclase 1 soluble subunit alpha, guanylate cyclase 1 soluble subunit alpha 1, GUCY1A3
External IDsOMIM: 139396 MGI: 1926562 HomoloGene: 37360 GeneCards: GUCY1A1
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q32.1Start155,666,711 bp[1]
End155,732,349 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2982

60596

Ensembl

ENSG00000164116

ENSMUSG00000033910

UniProt

Q02108
Q6PJR4

Q9ERL9

RefSeq (mRNA)

NM_021896
NM_001356987
NM_001356988

RefSeq (protein)

NP_068696
NP_001343916
NP_001343917

Location (UCSC)Chr 4: 155.67 – 155.73 MbChr 3: 82.09 – 82.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.[6] Mutations in this gene have been associated to cases of myocardial infarction (10.1038/nature12722).

References

  1. GRCh38: Ensembl release 89: ENSG00000164116 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033910 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Giuili G, Scholl U, Bulle F, Guellaen G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.
  6. "Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3".

Further reading


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