CCP110

Centriolar coiled-coil protein of 110 kDa also known as centrosomal protein of 110 kDa or CP110 is a protein that in humans is encoded by the CCP110 gene. It is a cell cycle-dependent CDK substrate and regulates centrosome duplication.[5][6] CP110 suppresses a cilia assembly program.[7]

CCP110
Identifiers
AliasesCCP110, CP110, Cep110, centriolar coiled-coil protein 110kDa, centriolar coiled-coil protein 110
External IDsOMIM: 609544 MGI: 2141942 HomoloGene: 8810 GeneCards: CCP110
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p12.3Start19,523,811 bp[1]
End19,553,408 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9738

101565

Ensembl

ENSG00000103540

ENSMUSG00000033904

UniProt

O43303

Q7TSH4

RefSeq (mRNA)

NM_182995
NM_001360793
NM_001360794

RefSeq (protein)

NP_892040
NP_001347722
NP_001347723

Location (UCSC)Chr 16: 19.52 – 19.55 MbChr 7: 118.71 – 118.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000103540 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033904 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD (September 2002). "CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells". Dev. Cell. 3 (3): 339–50. doi:10.1016/S1534-5807(02)00258-7. PMID 12361598.
  6. Li J, D'Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD (March 2013). "USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110". Nature. 495 (7440): 255–9. doi:10.1038/nature11941. PMC 3815529. PMID 23486064.
  7. Spektor A, Tsang WY, Khoo D, Dynlacht BD (August 2007). "Cep97 and CP110 suppress a cilia assembly program". Cell. 130 (4): 678–90. doi:10.1016/j.cell.2007.06.027. PMID 17719545. S2CID 17974875.

Further reading


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