CEP70

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene.[5][6] The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.[7]

CEP70
Identifiers
AliasesCEP70, BITE, centrosomal protein 70
External IDsOMIM: 614310 MGI: 1915371 HomoloGene: 11387 GeneCards: CEP70
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q22.3Start138,494,344 bp[1]
End138,594,538 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80321

68121

Ensembl

ENSG00000114107

ENSMUSG00000056267

UniProt

Q8NHQ1

Q6IQY5

RefSeq (mRNA)

NM_023873

RefSeq (protein)

NP_076362

Location (UCSC)Chr 3: 138.49 – 138.59 MbChr 9: 99.24 – 99.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000114107 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000056267 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
  6. "Entrez Gene: CEP70 centrosomal protein 70kDa".
  7. Shi X, Sun X, Liu M, Li D, Aneja R, Zhou J (September 2011). "CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly". J. Biol. Chem. 286 (38): 33401–8. doi:10.1074/jbc.M111.252262. PMC 3190865. PMID 21795687.

Further reading


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