CEP192

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene.[5][6] It is the homolog of the C. elegans and D. melanogaster gene SPD-2.[7]

CEP192
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCEP192, PPP1R62, centrosomal protein 192
External IDsOMIM: 616426 MGI: 1918049 HomoloGene: 73526 GeneCards: CEP192
Gene location (Human)
Chr.Chromosome 18 (human)[1]
Band18p11.21Start12,991,362 bp[1]
End13,125,052 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

55125

70799

Ensembl

ENSG00000101639

ENSMUSG00000024542

UniProt

Q8TEP8

n/a

RefSeq (mRNA)

NM_018069
NM_032142

NM_027556

RefSeq (protein)

NP_115518

n/a

Location (UCSC)Chr 18: 12.99 – 13.13 MbChr 18: 67.8 – 67.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells.[7] It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000101639 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024542 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: centrosomal protein 192kDa".
  6. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
  7. Zhu, F.; Lawo, S.; Bird, A.; Pinchev, D.; Ralph, A.; Richter, C.; Müller-Reichert, T.; Kittler, R.; Hyman, A.; Pelletier, L. (2008). "The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis". Current Biology. 18 (2): 136–141. doi:10.1016/j.cub.2007.12.055. PMID 18207742. S2CID 16159409.
  8. Gomez-Ferreria, M.; Rath, U.; Buster, D.; Chanda, S.; Caldwell, J.; Rines, D.; Sharp, D. (2007). "Human Cep192 is required for mitotic centrosome and spindle assembly". Current Biology. 17 (22): 1960–1966. doi:10.1016/j.cub.2007.10.019. PMID 17980596. S2CID 10245690.

Further reading


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