CHRNA5

Neuronal acetylcholine receptor subunit alpha-5, also known as nAChRα5, is a protein that in humans is encoded by the CHRNA5 gene.[5][6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

CHRNA5
Identifiers
AliasesCHRNA5, LNCR2, cholinergic receptor nicotinic alpha 5 subunit
External IDsOMIM: 118505 MGI: 87889 HomoloGene: 55485 GeneCards: CHRNA5
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q25.1Start78,565,520 bp[1]
End78,595,269 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1138

110835

Ensembl

ENSG00000169684

ENSMUSG00000035594

UniProt

P30532

Q2MKA5

RefSeq (mRNA)

NM_000745
NM_001307945

NM_176844
NM_001373901
NM_001373902

RefSeq (protein)

NP_000736
NP_001294874

NP_789814
NP_001360830
NP_001360831

Location (UCSC)Chr 15: 78.57 – 78.6 MbChr 9: 54.98 – 55.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.[6] CHRNA5 is a candidate gene for predisposition to nicotine dependence and to lung cancer risk. [7] Polymorphisms in the CHRNA5 promoter are functionally associated with CHRNA5 transcript levels in lung tissue. [8]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000169684 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035594 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–82. doi:10.1016/0888-7543(91)90253-B. PMID 2004777.
  6. "Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5".
  7. Hung et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 2008;452(7187):633–637.
  8. Falvella et al. Promoter polymorphisms and transcript levels of nicotinic receptor CHRNA5. J Natl Cancer Inst. 2010;102(17):1366–1370.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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