CHRNB1

Acetylcholine receptor subunit beta is a protein that in humans is encoded by the CHRNB1 gene.[5]

CHRNB1
Identifiers
AliasesCHRNB1, ACHRB, CHRNB, CMS1D, CMS2A, SCCMS, CMS2C, cholinergic receptor nicotinic beta 1 subunit
External IDsOMIM: 100710 MGI: 87890 HomoloGene: 594 GeneCards: CHRNB1
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.1Start7,445,061 bp[1]
End7,457,710 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1140

11443

Ensembl

ENSG00000170175
ENSG00000283946

ENSMUSG00000041189

UniProt

P11230

P09690

RefSeq (mRNA)

NM_000747

NM_009601

RefSeq (protein)

NP_000738

NP_033731

Location (UCSC)Chr 17: 7.45 – 7.46 MbChr 11: 69.78 – 69.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome.[5]

See also

References

  1. ENSG00000283946 GRCh38: Ensembl release 89: ENSG00000170175, ENSG00000283946 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041189 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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