CHRNB2

Neuronal acetylcholine receptor subunit beta-2 is a protein that in humans is encoded by the CHRNB2 gene.[5][6]

CHRNB2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCHRNB2, EFNL3, nAChRB2, cholinergic receptor nicotinic beta 2 subunit
External IDsOMIM: 118507 MGI: 87891 HomoloGene: 595 GeneCards: CHRNB2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q21.3Start154,567,778 bp[1]
End154,580,013 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1141

11444

Ensembl

ENSG00000160716

ENSMUSG00000027950

UniProt

P17787

Q9ERK7

RefSeq (mRNA)

NM_000748

NM_009602

RefSeq (protein)

NP_000739

NP_033732

Location (UCSC)Chr 1: 154.57 – 154.58 MbChr 3: 89.75 – 89.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.[6]

It has been discovered that suppression, rather than stimulation, of B2-containing nAChR currents yields an antidepressant effect. This is believed to explain the significantly increased prevalence of cigarette smoking in depressed individuals and the profound rise in depressive symptoms during abstinence.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000160716 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027950 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.
  6. "Entrez Gene: CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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