GABRG1

Gamma-aminobutyric acid receptor subunit gamma-1 is a protein that in humans is encoded by the GABRG1 gene.[5] The protein encoded by this gene is a subunit of the GABAA receptor.[6]

GABRG1
Identifiers
AliasesGABRG1, gamma-aminobutyric acid type A receptor gamma1 subunit, gamma-aminobutyric acid type A receptor subunit gamma1
External IDsOMIM: 137166 MGI: 103156 HomoloGene: 22570 GeneCards: GABRG1
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4p12Start46,035,769 bp[1]
End46,124,054 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

2565

14405

Ensembl

ENSG00000163285

ENSMUSG00000001260

UniProt

Q8N1C3

Q9R0Y8

RefSeq (mRNA)

NM_173536

NM_010252

RefSeq (protein)

NP_775807

NP_034382

Location (UCSC)Chr 4: 46.04 – 46.12 MbChr 5: 70.75 – 70.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Variants of this gene may be associated with alcohol dependence.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000163285 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000001260 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wilcox AS, Warrington JA, Gardiner K, Berger R, Whiting P, Altherr MR, Wasmuth JJ, Patterson D, Sikela JM (July 1992). "Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5857–5861. doi:10.1073/pnas.89.13.5857. PMC 49396. PMID 1321425.
  6. Hevers W, Lüddens H (August 1998). "The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes". Mol. Neurobiol. 18 (1): 35–86. doi:10.1007/BF02741459. PMID 9824848. S2CID 32359279.
  7. Ittiwut C, Listman J, Mutirangura A, Malison R, Covault J, Kranzler HR, Sughondhabirom A, Thavichachart N, Gelernter J (January 2008). "Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4". Genomics. 91 (1): 61–69. doi:10.1016/j.ygeno.2007.08.007. PMC 2709929. PMID 17976953.

Further reading

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