DNA polymerase alpha subunit 2

DNA polymerase alpha subunit 2 is an enzyme that in humans is encoded by the POLA2 gene.[5][6][7]

Shared primase-binding peptide in archaeal PolD and eukaryotic Polα
POLA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLA2, DNA polymerase alpha 2, accessory subunit
External IDsMGI: 99690 HomoloGene: 48121 GeneCards: POLA2
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start65,261,920 bp[1]
End65,305,589 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23649

18969

Ensembl

ENSG00000014138

ENSMUSG00000024833

UniProt

Q14181

P33611

RefSeq (mRNA)

NM_002689

NM_001164057
NM_008893

RefSeq (protein)

NP_002680

NP_001157529
NP_032919

Location (UCSC)Chr 11: 65.26 – 65.31 MbChr 19: 5.94 – 5.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

POLA2 has been shown to interact with PARP1.[8]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000014138 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024833 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Collins KL, Russo AA, Tseng BY, Kelly TJ (Dec 1993). "The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication". EMBO J. 12 (12): 4555–66. doi:10.1002/j.1460-2075.1993.tb06144.x. PMC 413886. PMID 8223465.
  6. Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE (Jul 2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase ɛ B-subunit gene POLE2". Nucleic Acids Res. 29 (13): 2810–21. doi:10.1093/nar/29.13.2810. PMC 55767. PMID 11433027.
  7. "Entrez Gene: POLA2 polymerase (DNA directed), alpha 2 (70kD subunit)".
  8. Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J (Apr 1998). "Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication". Nucleic Acids Res. 26 (8): 1891–8. doi:10.1093/nar/26.8.1891. PMC 147507. PMID 9518481.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA polymerase alpha subunit B



This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.