POLD2

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene.[5][6] It is a component of the DNA polymerase delta complex.

POLD2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLD2, DNA polymerase delta 2, accessory subunit
External IDsOMIM: 600815 MGI: 1097163 HomoloGene: 4538 GeneCards: POLD2
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7p13Start44,114,681 bp[1]
End44,124,358 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5425

18972

Ensembl

ENSG00000106628

ENSMUSG00000020471

UniProt

P49005

O35654

RefSeq (mRNA)

NM_001127218
NM_001256879
NM_006230

NM_008894
NM_001361942

RefSeq (protein)

NP_001120690
NP_001243808
NP_006221

NP_032920
NP_001348871

Location (UCSC)Chr 7: 44.11 – 44.12 MbChr 11: 5.87 – 5.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

POLD2 has been shown to interact with PCNA.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000106628 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020471 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhang J, Tan CK, McMullen B, Downey KM, So AG (Feb 1996). "Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2)". Genomics. 29 (1): 179–86. doi:10.1006/geno.1995.1229. PMID 8530069.
  6. "Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa".
  7. Lu, Xiaoqing; Tan Cheng-Keat; Zhou Jin-Qiu; You Min; Carastro L Michael; Downey Kathleen M; So Antero G (Jul 2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. United States. 277 (27): 24340–5. doi:10.1074/jbc.M200065200. ISSN 0021-9258. PMID 11986310.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P49005 (Human DNA polymerase delta subunit 2 (POLD2)) at the PDBe-KB.


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