Dihydrochelirubine 12-monooxygenase
In enzymology, a dihydrochelirubine 12-monooxygenase (EC 1.14.13.57) is an enzyme that catalyzes the chemical reaction
- dihydrochelirubine + NADPH + H+ + O2 12-hydroxydihydrochelirubine + NADP+ + H2O
| dihydrochelirubine 12-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.57 | ||||||||
| CAS number | 158736-41-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The 4 substrates of this enzyme are dihydrochelirubine, NADPH, H+, and O2, whereas its 3 products are 12-hydroxydihydrochelirubine, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating). This enzyme is also called dihydrochelirubine 12-hydroxylase. This enzyme participates in alkaloid biosynthesis i.
References
- Kammerer L, De-Eknamkul W, Zenk MH (1994). "Enzymic 12-hydroxylation and 12-O-methylation of dihydrochelirubine in dihydromacarpine formation by Thalictrum bulgaricum". Phytochemistry. 36 (6): 1409–1416. doi:10.1016/S0031-9422(00)89732-0.