Exodeoxyribonuclease I
Exodeoxyribonuclease I (EC 3.1.11.1, Escherichia coli exonuclease I, E. coli exonuclease I, exonuclease I) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction:
- Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
| Exodeoxyribonuclease I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.11.1 | ||||||||
| CAS number | 9037-46-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Preference for single-stranded DNA. The Escherichia coli enzyme hydrolyses glucosylated DNA. Punjabi
References
- Blakesley RW, Dodgson JB, Nes IF, Wells RD (October 1977). "Duplex regions in "single-stranded" phiX174 DNA are cleaved by a restriction endonuclease from Haemophilus aegyptius". The Journal of Biological Chemistry. 252 (20): 7300–6. PMID 71298.
- Kelley RB, Atkinson MR, Huberman JA, Kornberg A (1969). "Excision of thymine dimers and other mismatched sequences by DNA polymerases of Escherichia coli". Nature. 224: 495–501. doi:10.1038/224495a0.
- Lehman IR, Nussbaum AL (August 1964). "The deoxyribonucleases of Escherichia coli. V. On the specificity of exonuclease I (phosphodiesterase)". The Journal of Biological Chemistry. 239: 2628–36. PMID 14235546.
External links
- Exodeoxyribonuclease+I at the US National Library of Medicine Medical Subject Headings (MeSH)
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