Feruloyl esterase
In enzymology, a feruloyl esterase (EC 3.1.1.73) is an enzyme that catalyzes the chemical reaction
- feruloyl-polysaccharide + H2O ferulate + polysaccharide
| feruloyl esterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.1.73 | ||||||||
| CAS number | 134712-49-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are feruloyl-polysaccharide and H2O, whereas its two products are ferulate and polysaccharide.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is feruloyl esterase. Other names in common use include ferulic acid esterase (FAE), hydroxycinnamoyl esterase, hemicellulase accessory enzyme, cinnamoyl ester hydrolase (cinnAE).
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1USW, 1UWC, 1UZA, 2BJH, 2HL6, and 2IX9.
References
- Catherine Tomaro-Duchesneau; Shyamali Saha; Meenakshi Malhotra; Michael Coussa-Charley; Imen Kahouli; Mitchell L. Jones; Alain Labbe; Satya Prakash (2012). "Probiotic Ferulic Acid Esterase Active Lactobacillus fermentum NCIMB 5221 APA Microcapsules for Oral Delivery: Preparation and in Vitro Characterization". Pharmaceuticals. 5 (2): 236–248. doi:10.3390/ph5020236. PMC 3763630. PMID 24288090.
- D.B.R.K. Gupta Udatha; Irene Kouskoumvekaki; Lisbeth Olsson; Gianni Panagiotou (2011). "The interplay of descriptor-based computational analysis with pharmacophore modeling builds the basis for a novel classification scheme for feruloyl esterases". Biotechnology Advances. 29 (1): 94–110. doi:10.1016/j.biotechadv.2010.09.003. PMID 20851174.
- Faulds CB, Williamson G (1991). "The purification and characterization of 4-hydroxy-3-methoxycinnamic (ferulic) acid esterase from Streptomyces olivochromogenes". J. Gen. Microbiol. 137 (10): 2339–45. doi:10.1099/00221287-137-10-2339. PMID 1663152.
- Faulds CB, Williamson G (1994). "Purification and characterisation of a ferulic acid esterase (FAE-III) from Aspergillus niger. Specificity for the phenolic moiety and binding to microcrystalline cellulose". Microbiology. 140 (4): 779–787. doi:10.1099/00221287-140-4-779.
- Kroon PA, Faulds CB, Williamson G (June 1996). "Purification and characterization of a novel esterase induced by growth of Aspergillus niger on sugar-beet pulp". Biotechnol. Appl. Biochem. 23 (3): 255–62. PMID 8679110.
- Faulds CB, Williamson G, van den Hombergh JP, Visser J (1997). "The faeA genes from Aspergillus niger and Aspergillus tubingensis encode ferulic acid esterases involved in degradation of complex cell wall polysaccharides". Appl. Environ. Microbiol. 63 (12): 4638–44. doi:10.1128/AEM.63.12.4638-4644.1997. PMC 168785. PMID 9406381.
- Castanares A, Mccrae SI, Wood TM (1992). "Purification and properties of a feruloyl/p-coumaroyl esterase from the fungus Penicillium pinophilum". Enzyme and Microbial Technology. 14 (11): 875–884. doi:10.1016/0141-0229(92)90050-X.
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