Formononetin

Formononetin
Names
IUPAC name
7-hydroxy-3-(4-methoxyphenyl)chromen-4-one
Other names
Biochanin B
Formononetol
7-Hydroxy-4'-methoxyisoflavone
4'-O-methyldaidzein
Identifiers
3D model (JSmol)
237979
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.006.931
KEGG
UNII
Properties
C16H12O4
Molar mass 268.26 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Formononetin is an O-methylated isoflavone.

Natural occurrences

Formononetin is found in a number of plants and herbs such as red clover.[1] Along with other phytoestrogens, it predominantly occurs in leguminous plants and Fabaceae, particularly in beans, such as green beans, lima beans, soy and many others, as the free aglycone or in form of its glucoside ononin.[2]

It can also be found in Maackia amurensis cell cultures.[3]

Pharmacodynamics

Formononetin promotes angiogenesis.[4]

Derivatives

Ononin is the 7-O-β-D-glucopyranoside of formononetin.[5]

References
  1. Medjakovic, S.; Jungbauer, A. (2008). "Red Clover Isoflavones Biochanin A and Formononetin are Potent Ligands of the Human Aryl Hydrocarbon Receptor". The Journal of Steroid Biochemistry and Molecular Biology. 108 (1–2): 171–177. doi:10.1016/j.jsbmb.2007.10.001. PMID 18060767.
  2. "Iowa State University Database on the Isoflavone Content of Foods, Release 1.3". USDA. 2002. Archived from the original on 2012-11-02. Retrieved 2011-02-13.
  3. Fedoreyev, S.A; Pokushalova, T.V; Veselova, M.V; Glebko, L.I; Kulesh, N.I; Muzarok, T.I; Seletskaya, L.D; Bulgakov, V.P; Zhuravlev, Yu.N (2000). "Isoflavonoid production by callus cultures of Maackia amurensis". Fitoterapia. 71 (4): 365–72. doi:10.1016/S0367-326X(00)00129-5. PMID 10925005.
  4. Li, Shang; Dang, Yuanye; Zhou, Xuelin; Huang, Bin; Huang, Xiaohui; Zhang, Zherui; Kwan, Yiu Wa; Chan, Shun Wan; Leung, George Pak Heng; Lee, Simon Ming Yuen; Hoi, Maggie Pui Man (2015). "Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway". Scientific Reports. 5: 16815. doi:10.1038/srep16815. PMC 4645220. PMID 26568398.
  5. You-Ping Zhu (1998-05-28). Chinese Materia Medica: Chemistry, Pharmacology and Applications. p. 622. ISBN 9057022850.


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